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LAMA5 / Laminin Alpha 5

laminin, alpha 5

Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined.

Gene Name: laminin, alpha 5
Family/Subfamily: Laminin , not assigned-Laminin
Synonyms: LAMA5, KIAA0533, KIAA1907, Laminin alpha-5 chain, Laminin-10 subunit alpha, Laminin subunit alpha-5, Laminin, alpha 5, Laminin-11 subunit alpha, Laminin-15 subunit alpha
Target Sequences: NM_005560 NP_005551.3 O15230

Publications (2)

1
Laminin 511 is a target antigen in autoimmune pancreatitis. Masahiro Shiokawa, Yuzo Kodama, Kiyotoshi Sekiguchi, Takeshi Kuwada, Teruko Tomono, Katsutoshi Kuriyama, Hajime Yamazaki, Toshihiro Morita, Saiko Marui, Yuko Sogabe, Nobuyuki Kakiuchi, Tomoaki Matsumori, Atsushi Mima, Yoshihiro Nishikawa, Tatsuki Ueda, Motoyuki Tsuda, Yuki Yamauchi, Yojiro Sakuma, Takahisa Maruno, Norimitsu Uza, Tatsuaki Tsuruyama, Tsuneyo Mimori, Hiroshi Seno, Tsutomu Chiba. Science translational medicine. 2018 August;10: [Full Text Article] [PubMed:30089633] Related Antibodies: LS-C144882.
2
Biallelic mutations in LAMA5 disrupts a skeletal noncanonical focal adhesion pathway and produces a distinct bent bone dysplasia. Maya Barad, Fabiana Csukasi, Michaela Bosakova, Jorge H Martin, Wenjuan Zhang, S Paige Taylor, Ralph S Lachman, Jennifer Zieba, Michael Bamshad, Deborah Nickerson, Jessica X Chong, Daniel H Cohn, Pavel Krejci, Deborah Krakow, Ivan Duran. EBioMedicine. 2020 November;62:103075. [Full Text Article] [PubMed:33242826] [PMC:PMC7695969] Related Antibodies: LS-C352437.

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Proteins (4)
Recombinant (4)
LAMA5 / Laminin Alpha 5 (4)
No (4)
6His-SUMO, N-terminus (1)
GST (1)
GST, N-terminus (1)
His (1)
Human (3)
Mouse (1)
E. coli (2)
Wheat Germ Extract (2)
Purified (2)
LAMA5 / Laminin Alpha 5 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
LAMA5 / Laminin Alpha 5 Protein - 12.5% SDS-PAGE of human LAMA5 stained with Coomassie Blue
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Wheat Germ Extract
GST
100.4 kDa
2 µg/$439
LAMA5 / Laminin Alpha 5 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
LAMA5 / Laminin Alpha 5 Protein - Recombinant Laminin Alpha 5 By SDS-PAGE
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E. coli
His
23.2 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).