Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined.
|Gene Name:||laminin, alpha 5|
|Family/Subfamily:||Laminin , not assigned-Laminin|
|Synonyms:||LAMA5, KIAA0533, KIAA1907, Laminin alpha-5 chain, Laminin-10 subunit alpha, Laminin subunit alpha-5, Laminin, alpha 5, Laminin-11 subunit alpha, Laminin-15 subunit alpha|
|Target Sequences:||NM_005560 NP_005551.3 O15230|
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