LAMA4 / Laminin Alpha 4

laminin, alpha 4

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

☰ Filters

Products

Proteins (9)

Type

Over-Expression Lysate (4)

Recombinant (5)

Target

LAMA4 / Laminin Alpha 4 (9)

Publications

No (9)

Tag

GST (1)

His (4)

Myc-DDK (Flag) (4)

Species

Human (4)

Mouse (3)

Source

293T Cells (2)

E. coli (4)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

Select

Mouse LAMA4 / Laminin Alpha 4 Protein (Recombinant His) (aa457-630) - LS-G14702

Source:

E. coli

Tag:

His

Molecular Weight:

21.1 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

Select

Human LAMA4 / Laminin Alpha 4 Protein (Recombinant His) (aa832-1039) - LS-G14703

Source:

E. coli

Tag:

His

Molecular Weight:

24.6 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

Select

Mouse LAMA4 / Laminin Alpha 4 Protein (Recombinant His) (aa102-234) - LS-G14704

Source:

E. coli

Tag:

His

Molecular Weight:

16.2 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

Select

Mouse LAMA4 / Laminin Alpha 4 Protein (Recombinant His) (aa745-940) - LS-G14707

Source:

E. coli

Tag:

His

Molecular Weight:

23.3 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

Select

Human LAMA4 / Laminin Alpha 4 Protein (Recombinant GST) (Full Length) - LS-G29172

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

38.94 kDa

Price:

10 µg/$479; 25 µg/$670

Select

LAMA4 / Laminin Alpha 4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124106

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

202.52 kDa

Price:

100 µg/$710

Select

LAMA4 / Laminin Alpha 4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118064

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

201.82 kDa

Price:

100 µg/$710

Select

Human LAMA4 / Laminin Alpha 4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77069

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

202.52 kDa

Price:

20 µg/$215

Select

Human LAMA4 / Laminin Alpha 4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77070

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

201.82 kDa

Price:

20 µg/$215

Viewing 1-9 of 9 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.