LAIR1 / CD305

leukocyte-associated immunoglobulin-like receptor 1

Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.

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Products

Proteins (24)

Type

Over-Expression Lysate (4)

Recombinant (20)

Target

LAIR1 / CD305 (24)

Application

SDS-PAGE (4)

Publications

No (24)

Tag

6His, C-terminus (4)

6His, N-terminus (1)

AVI-6His, C-terminus (1)

Fc (2)

GST (1)

GST, N-terminus (1)

His (3)

His,C-terminus (2)

Human IgG Fc, C-terminus (2)

Mouse IgG Fc, C-terminus (1)

Myc-DDK (Flag) (5)

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Species

Human (16)

Mouse (5)

Rhesus monkey (1)

Source

293T Cells (2)

E. coli (3)

HEK 293 Cells (7)

Human (3)

Human Cells (5)

Mammalian Cells (2)

Wheat Germ Extract (2)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (14)

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LAIR1 / CD305 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110626

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.7 kDa

Price:

100 µg/$494

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Mouse LAIR1 / CD305 Protein (Recombinant 6His, C-terminus) (Gln22-Tyr141) - LS-G139263

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

14.4 kDa

Price:

10 µg/$277; 50 µg/$389

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Rhesus monkey LAIR1 / CD305 Protein (Recombinant 6His, C-terminus) - LS-G146313

Source:

Human

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

16.6 kDa

Price:

10 µg/$290; 50 µg/$446

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LAIR1 / CD305 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118068

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

31.2 kDa

Price:

100 µg/$494

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Human LAIR1 / CD305 Protein (Recombinant Mouse IgG Fc, C-terminus) - LS-G146064

Source:

Human

Tag:

Mouse IgG Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

41.8 kDa

Price:

10 µg/$290; 50 µg/$446

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Human LAIR1 / CD305 Protein (Recombinant AVI-6His, C-terminus) - LS-G146099

Source:

Human

Tag:

AVI-6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

18.1 kDa

Price:

20 µg/$416; 100 µg/$910

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Human LAIR1 / CD305 Protein (Recombinant GST) (Full Length) - LS-G29168

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

57.31 kDa

Price:

10 µg/$479; 25 µg/$670

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Human LAIR1 / CD305 Protein (Recombinant Human IgG Fc, C-terminus) (Met1-Tyr165) - LS-G51042

Source:

HEK 293 Cells

Tag:

Human IgG Fc, C-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human LAIR1 consists 385 amino acids and predicts a molecular mass of 42.8 kDa.

Price:

50 µg/$348; 1 mg/$2,003

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Human LAIR1 / CD305 Protein (Recombinant His,C-terminus) (Met1-Tyr165) - LS-G51057

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human LAIR1 consists of 155 amino acids and predicts a molecular mass of 17.2 kDa.

Price:

50 µg/$348; 1 mg/$2,003

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Mouse LAIR1 / CD305 Protein (Recombinant Human IgG Fc, C-terminus) (Gln22-Ser133) - LS-G48900

Source:

HEK 293 Cells

Tag:

Human IgG Fc, C-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant mouse LAIR1 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 353 amino acids and has a predicted molecular mass of 39.6 kDa. The apparent molecular mass of the protein is approximately 49-53 kDa in SDS-PAGE under reducing conditions due to glycosylation.

Price:

100 µg/$441; 1 mg/$2,003

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Mouse LAIR1 / CD305 Protein (Recombinant His,C-terminus) (Gln22-Ser133) - LS-G48901

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The secreted recombinant mouse LAIR1 comprises 123 amino acids and has a calculated molecular mass of 14 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 25-35 kDa in SDS-PAGE under reducing conditions.

Price:

100 µg/$441; 1 mg/$2,003

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Human LAIR1 / CD305 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67581

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

31.2 kDa

Price:

20 µg/$1,107

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Human LAIR1 / CD305 Protein (Recombinant GST, N-terminus) (aa188-287) - LS-G59094

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human LAIR1 / CD305 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80208

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

31.2 kDa

Price:

20 µg/$150

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Human LAIR1 / CD305 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80210

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.7 kDa

Price:

20 µg/$150

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Mouse LAIR1 / CD305 Protein (Recombinant His) (Gln22-Ser133) - LS-G98806

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

14 kDa

Price:

100 µg/$721

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Human LAIR1 / CD305 Protein (Recombinant Fc) (Met1-Tyr165) - LS-G97645

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

42.8 kDa

Price:

50 µg/$483

Select

Human LAIR1 / CD305 Protein (Recombinant His) (Met1-Tyr165) - LS-G97646

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

17.2 kDa

Price:

50 µg/$483

Select

Mouse LAIR1 / CD305 Protein (Recombinant Fc) (Gln22-Ser133) - LS-G98207

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

39.6 kDa

Price:

100 µg/$721

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Human LAIR1 / CD305 Protein (Recombinant) - LS-G3488

Source:

E. coli

Tag:

None

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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Human LAIR1 / CD305 Protein (Recombinant 6His, C-terminus) (Gln22-His163) - LS-G38893

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

16.5kD

Price:

10 µg/$262; 50 µg/$365; 500 µg/$1,585; 1 mg/$2,157

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Human LAIR1 / CD305 Protein (Recombinant 6His, N-terminus) (Gln22-His163) - LS-G26511

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

17.8 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365

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Human LAIR1 / CD305 Protein (Recombinant 6His, C-terminus) (Gln22-His163) - LS-G138891

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

16.5 kDa

Price:

10 µg/$262; 50 µg/$361

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Human LAIR1 / CD305 Protein (Recombinant His) (aa40-208) - LS-G13197

Source:

E. coli

Tag:

His

Molecular Weight:

20.3 kDa

Price:

10 µg/$260; 50 µg/$335; 100 µg/$497; 200 µg/$622; 1 mg/$1,588; 500 µg/$1,185; 5 mg/$2,522; 2 mg/$1,760

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