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LAG3
lymphocyte-activation gene 3
Lymphocyte-Activation Protein 3 (LAG3) belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.
| Gene Name: | lymphocyte-activation gene 3 |
| Synonyms: | LAG3, CD223 antigen, LAG-3, Protein FDC, CD223, FDC, Lymphocyte-activation gene 3 |
| Target Sequences: | NM_002286 P18627 P18627 |
Publications (15)
1
The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints. Llosa NJ, Cruise M, Tam A, Wicks EC, Hechenbleikner EM, Taube JM, Blosser RL, Fan H, Wang H, Luber BS, Zhang M, Papadopoulos N, Kinzler KW, Vogelstein B, Sears CL, Anders RA, Pardoll DM, Housseau F. Cancer discovery. 2015 5:43-51. (ELISA; Human)
[Full Text Article]
[PubMed:25358689]
[PMC:PMC4293246]
2
LAG3 expression in active Mycobacterium tuberculosis infections. Phillips BL, Mehra S, Ahsan MH, Selman M, Khader SA, Kaushal D. The American journal of pathology. 2015 185:820-33. (IHC; Macaque)
[Full Text Article]
[PubMed:25549835]
[PMC:PMC4348466]
3
Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade. Taube JM, Young GD, McMiller TL, Chen S, Salas JT, Pritchard TS, Xu H, Meeker AK, Fan J, Cheadle C, Berger AE, Pardoll DM, Topalian SL. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015 21:3969-76. (IHC; Human)
[Full Text Article]
[PubMed:25944800]
[PMC:PMC4558237]
☰ Filters
Products
Proteins
(30)
Type
Over-Expression Cell Culture Supernatant
(1)
Over-Expression Lysate
(3)
Recombinant
(26)
Target
LAG3
(30)
Publications
No
(30)
Tag
6His, C-terminus
(4)
6His, N-terminus
(4)
AVI-6His, C-terminus
(1)
DDK (Flag)-His, C-terminus
(1)
Fc
(1)
Fc, C-terminus
(4)
GST
(1)
GST-6His, N-terminus
(1)
His, C-Terminal
(1)
His,C-terminus
(2)
His,N-terminus
(1)
His-T7
(3)
Human IgG1 Fc
(1)
Human IgG1 Fc, N-terminus
(1)
Human IgG2a Fc
(1)
mFc, C-terminus
(1)
Myc-DDK (Flag)
(2)
Species
Crab-eating macaque
(2)
Human
(21)
Mouse
(4)
Rat
(2)
Source
293T Cells
(1)
CHO Cells
(2)
E. coli
(5)
HEK 293 Cells
(8)
Human
(2)
Human Cells
(4)
Mammalian Cells
(7)
Wheat Germ Extract
(1)
Purification
Purified
(8)
Low Endotoxin Level
Low endotoxin level
(17)
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
45.5kD
10 µg/$277; 50 µg/$395; 500 µg/$1,203; 1 mg/$1,627
E. coli
His-T7
28.8 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
Human
His, C-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
47.2kD
50 µg/$395; 500 µg/$1,262; 1 mg/$1,627; 10 µg/$277
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
73.3kD
50 µg/$395; 500 µg/$1,262; 1 mg/$1,627; 10 µg/$277
E. coli
GST-6His, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
72.3 kDa
50 µg/$483; 500 µg/$2,949
E. coli
His-T7
30.2 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
E. coli
His-T7
29.5 kDa
10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225
HEK 293 Cells
6His, N-terminus
50 kDa
10 µg/$289; 50 µg/$360; 100 µg/$432
Wheat Germ Extract
GST
65.5 kDa
2 µg/$439
HEK 293 Cells
6His, N-terminus
39 kDa
100 µg/$298
E. coli
6His, N-terminus
38.8 kDa
10 µg/$265; 50 µg/$315
HEK 293 Cells
6His, N-terminus
39 kDa
200 µl/$283
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
46.2kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
47.1 kDa
100 µg/$721
Mammalian Cells
mFc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
72.7 kDa
10 µg/$266; 50 µg/$361
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
46.2 kDa
10 µg/$317; 50 µg/$524
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
73.6 kDa
10 µg/$317; 50 µg/$524
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
73.3 kDa
10 µg/$277; 50 µg/$389
HEK 293 Cells
Human IgG1 Fc, N-terminus
Less than 5.0 EU/mg protein (determined by LAL method).
~95 kDa (SDS-PAGE)
50 µg/$456
Human
AVI-6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
49 kDa
20 µg/$416; 100 µg/$910
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
47.2 kDa
10 µg/$277; 50 µg/$389
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
45.5 kDa
10 µg/$277; 50 µg/$389
Mammalian Cells
His,N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
47.3 kDa
10 µg/$339; 50 µg/$437
HEK 293 Cells
DDK (Flag)-His, C-terminus
48 kDa
20 µg/$1,107
Viewing 1-25
of 30
product results
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