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L1CAM

L1 cell adhesion molecule

L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.

Gene Name: L1 cell adhesion molecule
Family/Subfamily: Immunoglobulin , not assigned-Immunoglobulin
Synonyms: L1CAM, CAML1, CD171 antigen, HSAS, HSAS1, MASA, MIC5, N-CAM-L1, N-CAML1, L1 cell adhesion molecule, NCAM-L1, S10, SPG1, CD171
Target Sequences: NP_000416.1 P32004

Publications (3)

1
An antibody against L1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent DNA damage. Jae-Kyung Nam , A-Ram Kim , Seo-Hyun Choi , Ji-Hee Kim, Kyu Jin Choi, Seulki Cho, Jae Won Lee, Hyun-Jai Cho, Yoo-Wook Kwon, Jaeho Cho, Kwang Seok Kim, Joon Kim, Hae-June Lee, Tae Sup Lee, Sangwoo Bae, Hyo Jeong Hong, Yoon-Jin Lee. Nature communications. 2021 June;12:3279. [Full Text Article] [PubMed:34078883] [PMC:PMC8172563] Related Antibodies: LS-B9803.
2
Neuronal-derived extracellular vesicles are enriched in the brain and serum of HIV-1 transgenic rats. Raghubendra Singh Dagur, Ke Liao, Susmita Sil, Fang Niu, Zhiqiang Sun, Yuri L Lyubchenko, Eric S Peeples, Guoku Hu, Shilpa Buch. Journal of Extracellular Vesicles. 2020 Dec;9:1703249. [Full Text Article] [PubMed:32002168] [PMC:PMC6968593] Related Antibodies: LS-C470565.
3
Preoperative Risk Stratification of Endometrial Carcinoma: L1CAM as a Biomarker. Annukka Pasanen, Mikko Loukovaara, Taru Tuomi, Ralf Bützow. The Breast : official journal of the European Society of Mastology. 2017 Sep;;27:1318-1324. [Full Text Article] [PubMed:29059097]

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L1CAM (15)
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96-Well Strip Plate (11)
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Serum (8)
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L1CAM ELISA Kit
Select
Sandwich
96-Well Microplate
Human
93.75 - 6000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
L1CAM ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$782
L1CAM ELISA Kit
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Sandwich
96-Well Microplate
Human
0.8 - 200 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$700
L1CAM ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
4.688 - 300 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
L1CAM ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
93.75 - 6000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
L1CAM ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
93.75 - 6000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
L1CAM ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
3.75 - 240 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
L1CAM ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,182; 1000 Wells/$1,747
L1CAM ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
L1CAM ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
L1CAM ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$783
L1CAM ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
L1CAM ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
93.75 - 6000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
L1CAM ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$764
L1CAM ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$818
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).