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Kv10.1 / KCNH1

potassium voltage-gated channel, subfamily H (eag-related), member 1

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.

Gene Name: potassium voltage-gated channel, subfamily H (eag-related), member 1
Family/Subfamily: Ion Channel , Potassium channel - Eag-related
Synonyms: KCNH1, EAG1, EAG, EAG channel 1, HEAG1, H-eag, Kv10.1
Target Sequences: NM_002238 NP_002229.1 O95259

Publications (2)

1
Purification of an EH domain-binding protein from rat brain that modulates the gating of the rat ether--go-go channel. Piros ET, Shen L, Huang XY. The Journal of biological chemistry. 1999 274:33677-83. [PubMed:10559257]
2
Human ether--go-go gene potassium channels are regulated by EGFR tyrosine kinase. Wu W, Dong MQ, Wu XG, Sun HY, Tse HF, Lau CP, Li GR. Biochimica et biophysica acta. 2012 1823:282-9. [PubMed:22061963]

☰ Filters
Products
Proteins (6)
Over-Expression Lysate (4)
Recombinant (2)
Kv10.1 / KCNH1 (6)
No (6)
ABP-His, N-terminus (1)
GST, N-terminus (1)
Myc-DDK (Flag) (4)
Human (4)
293T Cells (2)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Kv10.1 / KCNH1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
108.4 kDa
20 µg/$215
Kv10.1 / KCNH1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
111.2 kDa
20 µg/$215
Kv10.1 / KCNH1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
111.2 kDa
100 µg/$710
Kv10.1 / KCNH1 Protein
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E. coli
ABP-His, N-terminus
26.9 kDa
50 µg/$419
Kv10.1 / KCNH1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
108.4 kDa
100 µg/$710
Kv10.1 / KCNH1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).