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KRT86 / Keratin 86 / KRTHB6
keratin 86
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix.
| Gene Name: | keratin 86 |
| Synonyms: | KRT86, HB1, HHb6, Keratin protein HB6, Keratin 86, Keratin, type II cuticular Hb6, K86, Keratin-86, KRTHB6, MNX, Type II hair keratin Hb6, Type-II keratin Kb26, Hair keratin K2.11, Hard keratin, type II, 6, HB6, KRTHB1 |
| Target Sequences: | NP_002275.1 O43790 |
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