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KRT19 / CK19 / Cytokeratin 19

keratin 19

KRT19 / CK19 / Cytokeratin 19 is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21.

Gene Name:	keratin 19
Synonyms:	KRT19, CK19, Cytokeratin 19, Cytokeratin-19, Keratin 19, Keratin-19, CK-19, K19, K1CS, Keratin, type I, 40-kd
Target Sequences:	NM_002276 NP_002267.2 P08727

Publications (5)

Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease. Takeda K, Kojima Y, Ikejima K, Harada K, Yamashina S, Okumura K, Aoyama T, Frese S, Ikeda H, Haynes NM, Cretney E, Yagita H, Sueyoshi N, Sato N, Nakanuma Y, Smyth MJ, Okumura K. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:10895-900. [PubMed:18667695] [PMC:PMC2504811]

A case of primary combined neuroendocrine carcinoma with squamous cell carcinoma in the upper gingiva. Mochizuki Y, Omura K, Sakamoto K, Nakanishi S, Satoh K, Marukawa E, Yamaguchi A. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2010 109:e34-9. (IHC) [PubMed:20303044]

Analysis of compound heterozygotes reveals that the mouse floxed Pax6 (tm1Ued) allele produces abnormal eye phenotypes. Dorà NJ, Crookshanks AJ, Leung KK, Simpson TI, , Mason JO, Price DJ, West JD. Transgenic research. 2016 25:679-92. (ELISA; Mouse) [Full Text Article] [PubMed:27240603] Related Antibodies: LS-B108.

Establishment and Characterization of a New Human Intrahepatic Cholangiocarcinoma Cell Line LIV27. Xiwei Ding, Kais Zakharia, Catherine D Moser, Nellie A Campbell, Chunling Hu, Nataliya Razumilava, Roongruedee Chaiteerakij, Hassan M Shaleh, Patricia T Greipp, Rondell P Graham, Xiaoping Zou, Vishal S Chandan, Lewis R Roberts. Cancers. 2022 October;14: [Full Text Article] [PubMed:36291862] [PMC:PMC9600735] Related Antibodies: LS-B3148.

Hemizygous Le-Cre transgenic mice have severe eye abnormalities on some genetic backgrounds in the absence of LoxP sites. Dor[Character e0] NJ, Collinson JM, Hill RE, West JD. PloS one. 9:e109193. [Full Text Article] [PubMed:25272013] [PMC:PMC4182886] Related Antibodies: LS-B108.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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