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KRT18 / CK18 / Cytokeratin 18

keratin 18

KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis.

Gene Name:	keratin 18
Family/Subfamily:	Keratin , not assigned-Keratin
Synonyms:	KRT18, CK-18, Cytokeratin 18, Cytokeratin-18, K18, Keratin 18, CYK18, Keratin-18
Target Sequences:	NM_000224 NP_000215.1 P05783

Publications (2)

Inhibition of peroxisome proliferator-activated receptor gamma increases estrogen receptor-dependent tumor specification. Yin Y, Yuan H, Zeng X, Kopelovich L, Glazer RI. Cancer research. 2009 69:687-94. (IHC) [PubMed:19147585]

Haploinsufficiency of Def activates p53-dependent TGF beta signalling and causes scar formation after partial hepatectomy. Zhu Z, Chen J, Xiong JW, Peng J. PloS one. 2014 9:e96576. [Full Text Article] [PubMed:24801718] [PMC:PMC4011785] Related Antibodies: LS-C22655.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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