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KRAS

Kirsten rat sarcoma viral oncogene homolog

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. Mutations in this gene are associated with leukemia, lung, breast, bladder, pancreatic, and stomach cancer.

Gene Name: Kirsten rat sarcoma viral oncogene homolog
Family/Subfamily: Ras GTPase superfamily IPR001806 , RAS oncogene
Synonyms: KRAS, C-K-RAS, C-Ki-ras, C-Kirsten-ras protein, GTPase KRas, K-ras p21 protein, K-RAS2B, K-RAS2, KRAS2, NS, NS3, K-RAS4A, KRAS1, RASK2, Transforming protein p21, Oncogene KRAS2, K-Ras 2, K-RAS2A, K-RAS4B, KI-RAS, PR310 c-K-ras oncogene
Target Sequences: NM_004985 NP_203524.1 P01116

Publications (2)

1
Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange. Guillard S, Kolasinska-Zwierz P, Debreczeni J, Breed J, Zhang J, Bery N, Marwood R, Tart J, Overman R, Stocki P, Mistry B, Phillips C, Rabbitts T, Jackson R, Minter R. Nature communications. 2017 July;8:16111. (Human) [Full Text Article] [PubMed:28706291] [PMC:PMC5519984] Related Antibodies: LS-C175665.
2
Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling. Alexander N Kapustin, Paul Davey, David Longmire, Carl Matthews, Emily Linnane, Nitin Rustogi, Maria Stavrou, Paul W A Devine, Nicholas J Bond, Lyndsey Hanson, Silvia Sonzini, Alexey Revenko, A Robert MacLeod, Sarah Ross, Elisabetta Chiarparin, Sanyogitta Puri. Communications biology. 2021 Nov;4:1241. [Full Text Article] [PubMed:34725463] [PMC:PMC8560811] Related Antibodies: LS-C175665.

☰ Filters
Products
Proteins (20)
Over-Expression Lysate (4)
Recombinant (16)
KRAS (20)
No (20)
6His, N-terminus (6)
GST (1)
GST, N-terminus (1)
His (4)
His-T7 (1)
Myc-DDK (Flag) (6)
Myc-DDK (Flag), C-terminus (1)
Human (18)
293T Cells (2)
E. coli (11)
HEK 293 Cells (5)
Wheat Germ Extract (2)
Purified (4)
Low endotoxin level (6)
KRAS Protein - 12.5% SDS-PAGE of human KRAS stained with Coomassie Blue
Select
Wheat Germ Extract
GST
46.42 kDa
10 µg/$479; 25 µg/$670
KRAS Protein - Recombinant Human KRAS(G12C, N-6His)
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
23.6 kDa
10 µg/$258; 50 µg/$352
KRAS Protein - Purified recombinant protein KRAS was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
21.2 kDa
20 µg/$1,107
KRAS Protein
Select
E. coli
His
100 µg/$342; 500 µg/$641; 20 µg/$254
KRAS Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Select
293T Cells
Myc-DDK (Flag)
21.2 kDa
20 µg/$150
KRAS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
21.2 kDa
100 µg/$494
KRAS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
21.5 kDa
100 µg/$494
KRAS Protein
Select
HEK 293 Cells
Myc-DDK (Flag), C-terminus
21.2 kDa
20 µg/$1,107
KRAS Protein - Recombinant Human KRAS(G12V, N-6His)
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
23.6 kDa
10 µg/$258; 50 µg/$352
KRAS Protein - Recombinant Human KRAS(G12S, N-6His)
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
23.6 kDa
10 µg/$258; 50 µg/$352
KRAS Protein - Recombinant Human KRAS4B(G12C, N-6His)
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.5 kDa
10 µg/$258; 50 µg/$352
KRAS Protein - Recombinant Human KRAS4B (N-6His)
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.5 kDa
10 µg/$258; 50 µg/$352
KRAS Protein - Recombinant Human KRAS4B(G12V, N-6His)
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.4 kDa
10 µg/$258; 50 µg/$352
KRAS Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Select
E. coli
His
23.2 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
KRAS Protein - Recombinant  V-Ki-Ras2\xa0Kirsten\xa0Rat\xa0Sarcoma\xa0Viral\xa0Oncogene\xa0Homolog\xa0(KRAS) By SDS-PAGE
Select
E. coli
His-T7
25.4 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
KRAS Protein - Purified recombinant protein KRAS was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
21.5 kDa
20 µg/$1,107
KRAS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
21.5 kDa
20 µg/$150
Select
E. coli
His
22.5 kDa
50 µg/$721
Viewing 1-20 of 20 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).