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KPNA5

karyopherin alpha 5 (importin alpha 6)

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Gene Name: karyopherin alpha 5 (importin alpha 6)
Synonyms: KPNA5, Importin subunit alpha-6, Karyopherin subunit alpha-5, IPOA6, Importin alpha 6, SRP6
Target Sequences: NM_002269 NP_002260.2 O15131

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Products
Antibodies (26)
Primary (26)
KPNA5 (26)
Human (26)
Mouse (3)
Rat (2)
Bovine (3)
Chimpanzee (3)
Dog (3)
Gibbon (3)
Horse (3)
Monkey (3)
Rabbit (3)
IHC (5)
IHC-P (4)
WB (24)
ELISA (12)
ICC (1)
IF (1)
Peptide-ELISA (1)
RNAi (1)
rabbit (25)
mouse (1)
Product Group
IHCPlus (2)
IgG (24)
IgG1,k (1)
monoclonal mc (1)
polyclonal pc (25)
1D2 (1)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (2)
Unconjugated (13)
aa1-30 (7)
aa434-483 (4)
No (26)
KPNA5 Antibody - Anti-KPNA5 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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KPNA5 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
KPNA5 Antibody - Anti-KPNA5 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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KPNA5 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
0.05 mg/$460
KPNA5 Antibody - Immunohistochemistry of paraffin-embedded human testis tissue at dilution 1:100
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KPNA5 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
KPNA5 Antibody - KPNA5 monoclonal antibody (M01), clone 1D2 Western Blot analysis of KPNA5 expression in HepG2.
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KPNA5 Mouse anti-Human Monoclonal (1D2) Antibody
Human
ELISA, RNAi, WB
Unconjugated
100 µg/$423
KPNA5 Antibody - Immunohistochemistry of paraffin-embedded human brain tissue at dilution 1:100
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KPNA5 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
KPNA5 Antibody - Western blot analysis of extracts of various cell lines.
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KPNA5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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KPNA5 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
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KPNA5 Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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KPNA5 Rabbit anti-Human Polyclonal (aa1-30) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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KPNA5 Rabbit anti-Human Polyclonal (aa1-30) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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KPNA5 Rabbit anti-Human Polyclonal (aa1-30) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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KPNA5 Rabbit anti-Human Polyclonal (aa1-30) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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KPNA5 Rabbit anti-Human Polyclonal (aa1-30) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
KPNA5 Antibody - Western blot analysis of extracts of 3T3 cells using KPNA5 antibody. The lane on the left was treated with blocking peptide.
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KPNA5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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KPNA5 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
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KPNA5 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$937
Select
KPNA5 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$937
Select
KPNA5 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$937
Select
KPNA5 Rabbit anti-Human Polyclonal (PE) Antibody
Human
WB
PE Conjugated
100 µl/$937
Select
KPNA5 Rabbit anti-Human Polyclonal (APC) Antibody
Human
WB
APC Conjugated
100 µl/$937
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KPNA5 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$749
KPNA5 Antibody - Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KPNA5 Rabbit anti-Human Polyclonal (aa434-483) Antibody
Human
WB
Unconjugated
100 µl/$424
KPNA5 Antibody - Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KPNA5 Rabbit anti-Human Polyclonal (aa434-483) (Biotin) Antibody
Rabbit, Dog, Bovine, Horse, Gibbon, Human, Monkey, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
KPNA5 Antibody - Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KPNA5 Rabbit anti-Human Polyclonal (aa434-483) (FITC) Antibody
Rabbit, Dog, Bovine, Horse, Gibbon, Human, Monkey, Chimpanzee
WB
FITC Conjugated
100 µl/$469
KPNA5 Antibody - KPNA5 Antibody western blot of HepG2 cell line lysates (35 ug/lane). The KPNA5 antibody detected the KPNA5 protein (arrow).
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KPNA5 Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
WB
Unconjugated
400 µl/$393
Viewing 1-25 of 26 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).