KPNA3 / Importin Alpha 4

karyopherin alpha 3 (importin alpha 4)

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

KPNA3 / Importin Alpha 4 (5)

Publications

No (5)

Tag

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human KPNA3 / Importin Alpha 4 Protein (Recombinant GST, N-terminus) (aa422-521) - LS-G59080

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human KPNA3 / Importin Alpha 4 Protein (Recombinant His-T7) (aa3-220) - LS-G24941

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.0 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Human KPNA3 / Importin Alpha 4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76752

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.6 kDa

Price:

20 µg/$150

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Human KPNA3 / Importin Alpha 4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66014

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.6 kDa

Price:

20 µg/$1,107

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KPNA3 / Importin Alpha 4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99706

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.6 kDa

Price:

100 µg/$494

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