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KPNA3 / Importin Alpha 4

karyopherin alpha 3 (importin alpha 4)

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9.

Gene Name: karyopherin alpha 3 (importin alpha 4)
Synonyms: KPNA3, Importin alpha-3, Importin alpha Q2, Karyopherin subunit alpha-3, Importin-alpha-Q2, IPOA4, Qip2, SRP1, HSRP1, Importin alpha 4, Importin subunit alpha-3, SRP1-gamma, SRP1gamma, SRP4
Target Sequences: NM_002267 NP_002258.2 O00505

Publications (2)

1
Notch1 signaling is mediated by importins alpha 3, 4, and 7. Huenniger K, Krmer A, Soom M, Chang I, Khler M, Depping R, Kehlenbach RH, Kaether C. Cellular and molecular life sciences : CMLS. 2010 67:3187-96. [PubMed:20454918] [PMC:PMC3128743] Related Antibodies: LS-B2289.
2
Axotomy induces axonogenesis in hippocampal neurons by a mechanism dependent on importin . Ohara R, Hata K, Yasuhara N, Mehmood R, Yoneda Y, Nakagawa M, Yamashita T. Biochemical and biophysical research communications. 2011 405:697-702. (ICC; Rat) [PubMed:21291862] Related Antibodies: LS-B2289.

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Products
Antibodies (21)
Primary (21)
KPNA3 / Importin Alpha 4 (21)
Human (21)
Mouse (11)
Rat (8)
Bat (1)
Bovine (1)
Chicken (1)
Chimpanzee (3)
Dog (1)
Guinea pig (4)
Hamster (2)
Horse (1)
Monkey (5)
Pig (5)
Rabbit (1)
Xenopus (4)
Zebrafish (4)
IHC (8)
IHC-P (3)
WB (20)
ELISA (1)
ICC (2)
IF (3)
IP (2)
Peptide-ELISA (2)
rabbit (18)
goat (2)
rat (1)
Product Group
IHCPlus (2)
IgG (9)
IgG2a,l (1)
monoclonal mc (1)
polyclonal pc (20)
3D10 (1)
APC (1)
APC Conjugated (1)
Biotin Conjugated (3)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (10)
aa3-220 (8)
N-Terminus (4)
aa1-50 (2)
C Terminus (1)
aa509-521 (1)
No (20)
Yes (1)
KPNA3 / Importin Alpha 4 Antibody - Anti-KPNA3 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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KPNA3 / Importin Alpha 4 Goat anti-Human Polyclonal (aa509-521) Antibody
Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
KPNA3 / Importin Alpha 4 Antibody - Anti-KPNA3 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
KPNA3 / Importin Alpha 4 Antibody - Biotinylated antibody (1µg/ml) staining of Rat Testis lysate (35µg protein in RIPA buffer), exactly mirroring its parental non-biotinylated product. Primary incubation was 1 hour. Detected by chemiluminescence, using streptavidin-HRP and using NAP blocker
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KPNA3 / Importin Alpha 4 Goat anti-Human Polyclonal (C Terminus) (Biotin) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IP, Peptide-ELISA, WB
Biotin Conjugated
100 µg/$455
KPNA3 / Importin Alpha 4 Antibody - Detection of Human KPNA3 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-KPNA3 used at a dilution of 1:250.
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KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Human
IF, IHC
Unconjugated
100 µl/$500
KPNA3 / Importin Alpha 4 Antibody - Detection of Human KPNA3 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-KPNA3 used at a dilution of 1:200 (1 Detection: DAB.
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KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Human
IHC, IP, WB
Unconjugated
100 µl/$483
KPNA3 / Importin Alpha 4 Antibody - Immunohistochemical analysis of Karyopherin alpha-3 staining in human esophageal cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$276; 100 µl/$311; 200 µl/$376
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KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
60 µl/$280; 120 µl/$343; 200 µl/$451
KPNA3 / Importin Alpha 4 Antibody - Immunohistochemistry of paraffin-embedded human esophagus.
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KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
KPNA3 / Importin Alpha 4 Antibody
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KPNA3 / Importin Alpha 4 Rat anti-Mouse Monoclonal (3D10) Antibody
Mouse, Rat, Hamster, Human
WB
Unconjugated
100 µg/$406
KPNA3 / Importin Alpha 4 Antibody - Western blot of KPNA3 / Importin Alpha 4 antibody.
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KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (aa3-220) Antibody
Human
WB
Unconjugated
100 µl/$299; 200 µl/$341; 500 µl/$481; 1 ml/$551
KPNA3 / Importin Alpha 4 Antibody - Western blot of KPNA3 / Importin Alpha 4 antibody.
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KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (aa3-220) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$326; 200 µl/$383; 500 µl/$565; 1 ml/$702
KPNA3 / Importin Alpha 4 Antibody - Western blot of KPNA3 / Importin Alpha 4 antibody.
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KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (aa3-220) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$307; 200 µl/$355; 500 µl/$509; 1 ml/$594
KPNA3 / Importin Alpha 4 Antibody - Western blot of KPNA3 / Importin Alpha 4 antibody.
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KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (aa3-220) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$338; 200 µl/$397; 500 µl/$605; 1 ml/$756
KPNA3 / Importin Alpha 4 Antibody - Western blot of KPNA3 / Importin Alpha 4 antibody.
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KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (aa3-220) (Cy3) Antibody
Human
WB
Cy3 Conjugated
100 µl/$395; 200 µl/$481; 500 µl/$823; 1 ml/$898
KPNA3 / Importin Alpha 4 Antibody - Western blot of KPNA3 / Importin Alpha 4 antibody.
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KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (aa3-220) (APC, Cy7) Antibody
Human
WB
APC, Cy7 Conjugated
100 µl/$493; 200 µl/$646; 500 µl/$972; 1 ml/$1,168
KPNA3 / Importin Alpha 4 Antibody - Western blot of KPNA3 / Importin Alpha 4 antibody.
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KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (aa3-220) (PE) Antibody
Human
WB
PE Conjugated
100 µl/$395; 200 µl/$481; 500 µl/$823; 1 ml/$898
KPNA3 / Importin Alpha 4 Antibody - Western blot of KPNA3 / Importin Alpha 4 antibody.
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KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (aa3-220) (APC) Antibody
Human
WB
APC Conjugated
100 µl/$395; 200 µl/$481; 500 µl/$823; 1 ml/$898
KPNA3 / Importin Alpha 4 Antibody - MCF7 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Xenopus, Zebrafish, Pig, Rat, Mouse, Guinea pig, Human, Monkey
WB
Unconjugated
100 µl/$414
KPNA3 / Importin Alpha 4 Antibody - MCF7 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Xenopus, Zebrafish, Rat, Pig, Mouse, Guinea pig, Human, Monkey, Chimpanzee
WB
HRP Conjugated
100 µl/$459
KPNA3 / Importin Alpha 4 Antibody - MCF7 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Xenopus, Zebrafish, Rat, Pig, Mouse, Guinea pig, Human, Monkey, Chimpanzee
WB
Biotin Conjugated
100 µl/$459
KPNA3 / Importin Alpha 4 Antibody - MCF7 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
KPNA3 / Importin Alpha 4 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Xenopus, Zebrafish, Rat, Pig, Mouse, Guinea pig, Human, Monkey, Chimpanzee
WB
FITC Conjugated
100 µl/$459
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).