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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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KPNA2 / Importin Alpha 1

karyopherin alpha 2 (RAG cohort 1, importin alpha 1)

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination.

Gene Name: karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
Synonyms: KPNA2, Importin alpha 2, Importin subunit alpha-2, IPOA1, Importin alpha-2 subunit, Karyopherin subunit alpha-2, Importin-alpha-P1, Qip2, RAG cohort 1, SRP1, RCH1, SRP1-alpha, SRP1alpha, Importin alpha 1, Pendulin, RAG cohort protein 1
Target Sequences: NM_002266 NP_002257.1 P52292

Viewing 1-25 of 46 items
KPNA2 / Importin Alpha 1 Antibody - Anti-KPNA2 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Rabbit Polyclonal (IgG) to Human KPNA2 / Importin Alpha 1
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $425.00
KPNA2 / Importin Alpha 1 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal (IgG) to Human KPNA2 / Importin Alpha 1
Mouse, Human
IF, IHC, IHC-P, IP, WB
Unconjugated
50µl   $425.00
KPNA2 / Importin Alpha 1 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal (IgG) to Human KPNA2 / Importin Alpha 1
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50µl   1mg/ml   $425.00
KPNA2 / Importin Alpha 1 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal (IgG) to Human KPNA2 / Importin Alpha 1
Mouse, Human
IHC, IHC-P
Unconjugated
50µl   $425.00
KPNA2 / Importin Alpha 1 Antibody - Immunohistochemistry of paraffin-embedded human lymph node tissue using KPNA2 Antibody at dilution of 1:100
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Rabbit Polyclonal (IgG) to Human KPNA2 / Importin Alpha 1
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
Select
Mouse Monoclonal [clone 1E8B7] (IgG1) to Human KPNA2 / Importin Alpha 1
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
0.1mg   $365.00
KPNA2 / Importin Alpha 1 Antibody - Western blot of recombinant KPNA2 / Importin Alpha 1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human KPNA2 / Importin Alpha 1
Human
ICC, IP, WB
Unconjugated
100µl   0.5mg/ml   $255.00; 200µl   0.5mg/ml   $305.00; 500µl   0.5mg/ml   $445.00; 1ml   0.5mg/ml   $530.00
KPNA2 / Importin Alpha 1 Antibody - Western blot of recombinant KPNA2 / Importin Alpha 1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human KPNA2 / Importin Alpha 1
Human
WB
Biotin Conjugated
200µl   0.5mg/ml   $315.00; 500µl   0.5mg/ml   $465.00; 1ml   0.5mg/ml   $575.00
Select
Rabbit Polyclonal (IgG) to Human KPNA2 / Importin Alpha 1
Human
ELISA, IHC, WB
Unconjugated
100µg   $375.00
KPNA2 / Importin Alpha 1 Antibody - 1:100 staining human breast carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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Rabbit Polyclonal (IgG) to Human KPNA2 / Importin Alpha 1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
KPNA2 / Importin Alpha 1 Antibody - Detection of Human RCH1 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-RCH1 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
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Rabbit Polyclonal (IgG) to Human KPNA2 / Importin Alpha 1
Human
IHC, IP, WB
Unconjugated
100µl   1mg/ml   $395.00
Select
Rabbit Polyclonal (IgG) to Human KPNA2 / Importin Alpha 1
Mouse, Human
IF, WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
KPNA2 / Importin Alpha 1 Antibody
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Rat Monoclonal [clone 1A6] (IgG2a) to Human KPNA2 / Importin Alpha 1
Mouse, Rat, Hamster, Human
ICC, WB
Unconjugated
100µg   1mg/ml   $370.00
KPNA2 / Importin Alpha 1 Antibody - karyopherin alpha 2 antibody [C3], C-term detects karyopherin alpha 2 protein at cytoplasm and nucleus by immunofluorescent analysis. HeLa cells were fixed in ice-cold MeOH for 5 min. karyopherin alpha 2 protein stained by karyopherin alpha 2 antibody [C3], C-term diluted at 1:500.
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Rabbit Polyclonal (IgG) to Human KPNA2 / Importin Alpha 1
Mouse, Rat, Human
ICC, WB
Unconjugated
100µl   0.71mg/ml   $355.00
Select
Rabbit Polyclonal (IgG) to Human KPNA2 / Importin Alpha 1
Rat, Human
ELISA, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
KPNA2 / Importin Alpha 1 Antibody - Staining (top panel and green) of 4% formaldahyde-fixed HeLa with endogenously expressed HistonH2B-GFP fusion as DNA marker (mid panel and red). Data kindly provided by Francisco Iborra, MRC Mol. Haematol. Unit, Oxford.
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Goat Polyclonal to Human KPNA2 / Importin Alpha 1
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100µg   0.5mg/ml   $405.00
Select
Rabbit Polyclonal to Human KPNA2 / Importin Alpha 1
Human
IP, WB
Unconjugated
100µl   $385.00
Select
Mouse Monoclonal [clone 12K121] (IgG1) to Human KPNA2 / Importin Alpha 1
Human
ICC
Unconjugated
100µg   $650.00
Select
Mouse Monoclonal [clone 11n120] (IgG2a) to Human KPNA2 / Importin Alpha 1
Human
WB
Unconjugated
100µg   $650.00
KPNA2 / Importin Alpha 1 Antibody
Select
Mouse Monoclonal (IgG2a,k) to Human KPNA2 / Importin Alpha 1
Human
WB
Unconjugated
100µl   1mg/ml   $265.00; 200µl   1mg/ml   $305.00; 500µl   1mg/ml   $445.00; 1ml   1mg/ml   $545.00
KPNA2 / Importin Alpha 1 Antibody - Western blot of KPNA2 / Importin Alpha 1 antibody.
Select
Rat Monoclonal [clone 2G7] (IgG2a) to Human KPNA2 / Importin Alpha 1
Human
WB
Unconjugated
50µl   1mg/ml   $415.00
KPNA2 / Importin Alpha 1 Antibody - KPNA2 antibody Western blot of Transfected 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human KPNA2 / Importin Alpha 1
Rabbit, Mouse, Dog, Rat, Horse, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
KPNA2 / Importin Alpha 1 Antibody - Western blot analysis of KPNA2 using anti-KPNA2 antibody. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions. Lane 1: human Hela whole cell lysate,Lane 2: human HepG2 whole cell lysate. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-KPNA2 antigen affinity purified polyclonal antibody at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1% Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for KPNA2 at approximately 58KD. The expected band size for KPNA2 is at 58KD.
Select
Rabbit Polyclonal to Human KPNA2 / Importin Alpha 1
Human
WB
Unconjugated
100µg   $325.00
KPNA2 / Importin Alpha 1 Antibody - Western blot testing of human 1) HeLa and 2) HepG2 cell lysate with KPNA2 antibody at 0.5ug/ml. Predicted molecular weight: ~58 kDa.
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Rabbit Polyclonal (IgG) to Human KPNA2 / Importin Alpha 1
Human
WB
Unconjugated
100µg   $435.00
KPNA2 / Importin Alpha 1 Antibody - Biotinylated Goat Anti-KPNA2 / IPOA1 antibody (0.2µg/ml) staining of HeLa lysate (35µg protein in RIPA buffer), exactly mirroring its parental non-biotinylated product. Primary incubation was 1 hour. Detected by chemiluminescencence, using streptavidin-HRP and using NAP blocker as a substitute for skimmed milk.
Select
Goat Polyclonal to Human KPNA2 / Importin Alpha 1
Human
Peptide-ELISA, WB
Biotin Conjugated
100µg   0.5mg/ml   $405.00

Viewing 1-25 of 46 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).