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KMO

kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.

Gene Name: kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
Synonyms: KMO, DJ317G22.1, Kynurenine 3-hydroxylase, Kynurenine 3-monooxygenase
Target Sequences: NM_003679 NP_003670.2 O15229

Publications (1)

1
Kynurenine 3-monooxygenase upregulates pluripotent genes through ß-catenin and promotes triple-negative breast cancer progression. Tzu-Ting Huang, Ling-Ming Tseng, Ji-Lin Chen, Pei-Yi Chu, Chia-Han Lee, Chun-Teng Huang, Wan-Lun Wang, Ka-Yi Lau, Mei-Fang Tseng, Yuan-Ya Chang, Tzu-Yi Chiang, Yune-Fang Ueng, Hsin-Chen Lee, Ming-Shen Dai, Chun-Yu Liu. EBioMedicine. 2020 Apr;54:102717. [Full Text Article] [PubMed:32268268] [PMC:PMC7191260] Related Antibodies: LS-C165595.

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Antibodies (40)
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KMO (61)
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rabbit (36)
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monoclonal mc (1)
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KMO Antibody - Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with KMO Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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KMO Rabbit anti-Human Polyclonal (aa155-182) Antibody
Mouse, Human
Flo, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
400 µl/$393
KMO Antibody - Western Blot of Rabbit anti-KMO antibody. Lane 1: Brain Extract. Load: 10 ug per lane. Primary antibody: KMO antibody at 1ug/mL for overnight at 4 degrees C. Secondary antibody: IRDye800 alpha rabbit secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4 degrees C. Predicted/Observed size: 58 kDa for KMO. Other band(s): None.
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KMO Rabbit anti-Mouse Polyclonal (aa300-400) Antibody
Mouse, Human
WB
Unconjugated
100 µg/$567
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Yeast
6His, N-terminus
57.8 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
KMO Antibody - 1:100 staining mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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KMO Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
KMO Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.
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KMO Rabbit anti-Human Polyclonal (aa1-260) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
KMO Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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KMO Rabbit anti-Human Polyclonal (aa135-184) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
KMO Antibody - Western Blot of Rabbit anti-KMO antibody. Lane 1: Brain Extract. Load: 10 ug per lane. Primary antibody: KMO antibody at 1ug/mL for overnight at 4 degrees C. Secondary antibody: IRDye800 alpha rabbit secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4 degrees C. Predicted/Observed size: 58 kDa for KMO. Other band(s): Other bands at lower molecular weights. These bands are all specifically blocked by KMO peptide.
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KMO Rabbit anti-Mouse Polyclonal (aa200-300) Antibody
Mouse
ELISA, IF, IHC, WB
Unconjugated
100 µg/$567
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KMO Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$351
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KMO Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
KMO Antibody - Immunohistochemistry of paraffin-embedded human placenta tissue using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KMO Rabbit anti-Human Polyclonal (aa1-486) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
KMO Antibody - Immunohistochemistry of paraffin-embedded human placenta tissue using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KMO Rabbit anti-Human Polyclonal (aa1-486) (HRP) Antibody
Human
ELISA, IHC, IHC-P
HRP Conjugated
50 µg/$294; 100 µg/$360
KMO Antibody - Immunohistochemistry of paraffin-embedded human placenta tissue using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KMO Rabbit anti-Human Polyclonal (aa1-486) (Biotin) Antibody
Human
ELISA, IHC, IHC-P
Biotin Conjugated
50 µg/$294; 100 µg/$360
KMO Antibody - Immunohistochemistry of paraffin-embedded human placenta tissue using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KMO Rabbit anti-Human Polyclonal (aa1-486) (FITC) Antibody
Human
ELISA, IHC, IHC-P
FITC Conjugated
50 µg/$294; 100 µg/$360
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KMO Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$567
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KMO Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$567
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KMO Rabbit anti-Mouse Polyclonal (aa200-375) Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$567
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KMO Rabbit anti-Human Polyclonal (aa155-182) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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KMO Rabbit anti-Human Polyclonal (aa155-182) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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KMO Rabbit anti-Human Polyclonal (aa155-182) (Azide-free) Antibody
Human
ELISA, WB
Unconjugated, Azide-free
200 µl/$734
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KMO Rabbit anti-Human Polyclonal (aa155-182) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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KMO Rabbit anti-Human Polyclonal (aa155-182) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
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KMO Rabbit anti-Human Polyclonal (aa155-182) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
KMO Antibody - Goat Anti-kynurenine 3-monooxygenase Antibody (0.03µg/ml) staining of Human Placenta lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescencence.
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KMO Goat anti-Human Polyclonal Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
KMO Antibody - Goat Anti-kynurenine 3-monooxygenase (aa29-42) Antibody (1µg/ml) staining of Human Placenta lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescencence.
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KMO Goat anti-Human Polyclonal Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
KMO Antibody - KMO antibody Western Blot of OVCAR-3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KMO Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
Viewing 1-25 of 61 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).