KLRB1 / CD161

killer cell lectin-like receptor subfamily B, member 1

Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.

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Products

Proteins (9)

Type

Over-Expression Lysate (2)

Recombinant (7)

Target

KLRB1 / CD161 (9)

Application

SDS-PAGE (1)

Publications

No (9)

Tag

Fc, C-terminus (2)

GST, N-terminus (1)

His (2)

His,N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (6)

Mouse (2)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Human Cells (2)

Mammalian Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (4)

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Mouse KLRB1 / CD161 Protein (Recombinant His,N-terminus) (Gln67-His227) - LS-G49208

Source:

HEK 293 Cells

Tag:

His,N-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The secreted recombinant mouse Klrb1a comprises 180 amino acids and predicts a molecular mass of 21 kDa. As a result of glycosylation, the apparent molecular mass of mouse Klrb1a is approximately 30-35 kDa in SDS-PAGE under reducing conditions.

Price:

100 µg/$480

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Human KLRB1 / CD161 Protein (Recombinant Fc, C-terminus) (Gln67-Ser225) - LS-G40026

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

45.6kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353

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Human KLRB1 / CD161 Protein (Recombinant GST, N-terminus) (aa126-225) - LS-G59072

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human KLRB1 / CD161 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81442

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25.2 kDa

Price:

20 µg/$150

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Human KLRB1 / CD161 Protein (Recombinant His-T7) (aa73-188) - LS-G13176

Source:

E. coli

Tag:

His-T7

Molecular Weight:

17.3 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human KLRB1 / CD161 Protein (Recombinant Fc, C-terminus) (Gln67-Ser225) - LS-G140254

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

45.6 kDa

Price:

10 µg/$317; 50 µg/$524

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Human KLRB1 / CD161 Protein (Recombinant His) - LS-G1896

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Mouse KLRB1 / CD161 Protein (Recombinant His) (Gln67-His227) - LS-G98805

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

21 kDa

Price:

100 µg/$843

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KLRB1 / CD161 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118093

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25.2 kDa

Price:

100 µg/$494

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