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B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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KLK2 / Kallikrein 2
kallikrein-related peptidase 2
KLK2 / Kallikrein 2 is a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants.
| Gene Name: | kallikrein-related peptidase 2 |
| Family/Subfamily: | Protease , Serine S1 |
| Synonyms: | KLK2, Glandular kallikrein 2, Glandular kallikrein-1, HGK-1, Kallikrein 2, prostatic, Kallikrein-2, Kallikrein-related peptidase 2, KLK2A2, Tissue kallikrein-2 |
| Target Sequences: | NM_005551 NP_005542.1 P20151 |
Publications (1)
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