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Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis.
Gene Name: | kelch-like family member 42 |
Synonyms: | KLHL42, Ctb9, KLHDC5, Kelch domain containing 5, KIAA1340 |
Target Sequences: | AB037761 BAA92578.1 Q9P2K6 |
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