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KLHL25
kelch-like family member 25
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.
| Gene Name: | kelch-like family member 25 |
| Synonyms: | KLHL25, BTB/POZ KELCH domain protein, ENC-2, Ectodermal-neural cortex 2, ENC2, Kelch-like protein 25, Kelch-like 25 (Drosophila) |
| Target Sequences: | NM_022480 NP_071925.2 Q9H0H3 |
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