KLHL22

kelch-like family member 22

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

KLHL22 (5)

Publications

No (5)

Tag

GST (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (1)

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KLHL22 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G108646

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.5 kDa

Price:

100 µg/$494

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Human KLHL22 Protein (Recombinant GST) (Full Length) - LS-G35840

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

98.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human KLHL22 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69065

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.5 kDa

Price:

20 µg/$1,107

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Human KLHL22 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83779

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.5 kDa

Price:

20 µg/$150

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Human KLHL22 Protein (Recombinant His) (aa371-580) - LS-G140928

Source:

E. coli

Sequence Length:

209 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

23.1 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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