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Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.
Gene Name: | kelch-like family member 22 |
Synonyms: | KLHL22, Kelch-like 22 (Drosophila), Kelch-like protein 22, KELCHL |
Target Sequences: | NM_032775 NP_116164.2 Q53GT1 |
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