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KLF4

Kruppel-like factor 4 (gut)

Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.

Gene Name: Kruppel-like factor 4 (gut)
Synonyms: KLF4, EZF, GKLF, Kruppel-like factor 4 (gut), Hezf, Krueppel-like factor 4
Target Sequences: NM_004235 NP_004226.3 O43474

Publications (2)

1
Caveolin-3 Promotes a Vascular Smooth Muscle Contractile Phenotype. Gutierrez-Pajares JL, Iturrieta J, Dulam V, Wang Y, Pavlides S, Malacari G, Lisanti MP, Frank PG. Frontiers in cardiovascular medicine. 2015 2:27. (WB; Human) [Full Text Article] [PubMed:26664898] [PMC:PMC4671348] Related Antibodies: LS-B5641.
2
Immunohistochemical analysis of monocytic leukemias: usefulness of CD14 and Kruppel-like factor 4, a novel monocyte marker. Klco JM, Kulkarni S, Kreisel FH, Nguyen TD, Hassan A, Frater JL. American journal of clinical pathology. 2011 135:720-30. (IHC; Human) [Full Text Article] [PubMed:21502426] Related Antibodies: LS-B1192.

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KLF4 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$798
KLF4 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$651
KLF4 ELISA Kit
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Custom
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
1 Plate/$672
KLF4 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
18.75 - 1200 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$958
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).