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KLF12
Kruppel-like factor 12
Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | Kruppel-like factor 12 |
| Synonyms: | KLF12, AP-2rep transcription factor, AP-2 repressor, AP-2rep, HSPC122, Krueppel-like factor 12, Kruppel-like factor 12, AP2REP |
| Target Sequences: | NM_007249 NP_009180.3 Q9Y4X4 |
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