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KL / Klotho

klotho

May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1.

Gene Name: klotho
Synonyms: KL, Klotho
Target Sequences: NM_004795 NP_004786.2 Q9UEF7

Publications (4)

1
Soluble klotho as a marker of renal fibrosis and podocyte injuries in human kidneys. Cho NJ, Han DJ, Lee JH, Jang SH, Kang JS, Gil HW, Park S, Lee EY. PloS one. 2018 March;13:e0194617. (Human) [Full Text Article] [PubMed:29590173] [PMC:PMC5874023] Related Antibodies: LS-B6625.
2
Involvement of Klotho, TNF-a and ADAMs in radiation-induced senescence of renal epithelial cells. Da Yeon Kim, Minyoung Lee, Eun Ju Kim. Molecular medicine reports. 2021 January;23:1. [Full Text Article] [PubMed:33179086] [PMC:PMC7673348]
3
Protective effects of klotho on palmitate-induced podocyte injury in diabetic nephropathy. Jeong Suk Kang , Seung Seob Son, Ji-Hye Lee, Seong Woo Lee , Ah Reum Jeong, Eun Soo Lee, Seung-Kuy Cha, Choon Hee Chung, Eun Young Lee. PloS one. 2021 Apr;16:e0250666. [Full Text Article] [PubMed:33891667] [PMC:PMC8064606] Related Antibodies: LS-B6625.
4
Down-expression of klotho in canine mammary gland tumors and its prognostic significance. Heaji Chung, Sungin Lee, Geon A Kim, Wan Hee Kim. PloS one. 2022 June;17:e0265248. [Full Text Article] [PubMed:35666743] [PMC:PMC9170104] Related Antibodies: LS-B6625.
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Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
KL / Klotho (7)
No (7)
6His, N-terminus (1)
His (1)
His, N-Terminal (2)
Myc-DDK (Flag) (2)
Human (2)
Mouse (2)
Rat (2)
293T Cells (1)
CHO Cells (1)
E. coli (4)
HEK 293 Cells (1)
Purified (3)
Low endotoxin level (1)
Biologically active (1)
KL / Klotho Protein - Recombinant Klotho By SDS-PAGE
Select
E. coli
His
52.6 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
KL / Klotho Protein - Recombinant Klotho By SDS-PAGE
Select
E. coli
His, N-Terminal
52.6 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
Select
CHO Cells
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
65-70 kDa
5 µg/$268; 20 µg/$349
KL / Klotho Protein - Recombinant Klotho By SDS-PAGE
Select
E. coli
6His, N-terminus
83.5 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
KL / Klotho Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
116 kDa
20 µg/$215
KL / Klotho Protein - Recombinant Klotho (KL) by SDS-PAGE
Select
E. coli
His, N-Terminal
54.8kDa
10 µg/$279; 50 µg/$432; 200 µg/$862; 100 µg/$690; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,441
KL / Klotho Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
116 kDa
100 µg/$710
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).