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KL / Klotho
klotho
May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1.
| Gene Name: | klotho |
| Synonyms: | KL, Klotho |
| Target Sequences: | NM_004795 NP_004786.2 Q9UEF7 |
Publications (4)
1
Soluble klotho as a marker of renal fibrosis and podocyte injuries in human kidneys. Cho NJ, Han DJ, Lee JH, Jang SH, Kang JS, Gil HW, Park S, Lee EY. PloS one. 2018 March;13:e0194617. (Human)
[Full Text Article]
[PubMed:29590173]
[PMC:PMC5874023]
Related Antibodies: LS-B6625.
2
Involvement of Klotho, TNF-a and ADAMs in radiation-induced senescence of renal epithelial cells. Da Yeon Kim, Minyoung Lee, Eun Ju Kim. Molecular medicine reports. 2021 January;23:1. [Full Text Article]
[PubMed:33179086]
[PMC:PMC7673348]
3
Protective effects of klotho on palmitate-induced podocyte injury in diabetic nephropathy. Jeong Suk Kang , Seung Seob Son, Ji-Hye Lee, Seong Woo Lee , Ah Reum Jeong, Eun Soo Lee, Seung-Kuy Cha, Choon Hee Chung, Eun Young Lee. PloS one. 2021 Apr;16:e0250666. [Full Text Article]
[PubMed:33891667]
[PMC:PMC8064606]
Related Antibodies: LS-B6625.
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KL / Klotho Rabbit anti-Human Polyclonal (aa251-300) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
KL / Klotho Rabbit anti-Human Polyclonal (aa251-300) (Biotin) Antibody
Rabbit, Mouse, Dog, Guinea pig, Rat, Horse, Bat, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
KL / Klotho Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
KL / Klotho Rabbit anti-Human Polyclonal (aa720-769) Antibody
Human
IHC, IHC-P
Unconjugated
50 µl/$460
KL / Klotho Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
ELISA, IHC, WB
Unconjugated
100 µg/$832
KL / Klotho Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$393
KL / Klotho Rabbit anti-Mouse Polyclonal (aa100-149) Antibody
Mouse
WB
Unconjugated
100 µl/$424
KL / Klotho Goat anti-Human Polyclonal (aa424-436) Antibody
Rabbit, Mouse, Dog, Bovine, Hamster, Pig, Horse, Human
IHC-P, Peptide-ELISA
Unconjugated
100 µg/$503
KL / Klotho Rabbit anti-Human Polyclonal (aa467-516) Antibody
Human
WB
Unconjugated
100 µl/$424
KL / Klotho Rabbit anti-Human Polyclonal (aa61-110) Antibody
Human
WB
Unconjugated
100 µl/$424
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$902
E. coli
His
52.6 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
E. coli
His, N-Terminal
52.6 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
Sandwich
96-Well Microplate
Mouse
7.81 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$610
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Mouse
3.12 - 200 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$854
CHO Cells
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
65-70 kDa
5 µg/$268; 20 µg/$349
Sandwich
96-Well Strip Plate
Human
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
E. coli
6His, N-terminus
83.5 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
Sandwich
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
KL / Klotho Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
KL / Klotho Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
Competitive EIA
96-Well Strip Plate
Mouse
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$834
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