KIR2DS5

Killer Cell Immunoglobulin-like Receptor, Two Domains, Short Cytoplasmic Tail, 5

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

KIR2DS5 (3)

Publications

No (3)

Tag

GST (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

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Human KIR2DS5 Protein (Recombinant GST) - LS-G132109

Tag:

GST

Molecular Weight:

59.84kDa

Price:

10 µg/$479; 25 µg/$670

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Human KIR2DS5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87939

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.5 kDa

Price:

20 µg/$150

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KIR2DS5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113881

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.5 kDa

Price:

100 µg/$494

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