KIFAP3 / KAP3

kinesin-associated protein 3

The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene.

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Proteins (1)

Type

Recombinant (1)

Target

KIFAP3 / KAP3 (1)

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No (1)

Tag

GST (1)

Species

Human (1)

Source

Wheat Germ Extract (1)

Purification

Purified (1)

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Human KIFAP3 / KAP3 Protein (Recombinant GST) (Full Length) - LS-G32676

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

113.52 kDa

Price:

10 µg/$479; 25 µg/$670

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