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KIFAP3 / KAP3
kinesin-associated protein 3
The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | kinesin-associated protein 3 |
| Synonyms: | KIFAP3, DJ190I16.1, FLA3, KIF3AP, KAP-1, KAP-3, Smg GDS-associated protein, Smg-GDS, SMAP, KAP3, Kinesin-associated protein 3 |
| Target Sequences: | NM_014970 NP_055785.2 Q92845 |
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