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KIF2A

kinesin heavy chain member 2A

Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.

Gene Name:	kinesin heavy chain member 2A
Synonyms:	KIF2A, KNS2, KIF2, Kinesin heavy chain member 2A, Kinesin heavy chain member 2, Kinesin, heavy chain, 2, Kinesin-like protein KIF2A, Kinesin-2
Target Sequences:	NM_004520 NP_004511.2 O00139

Publications (4)

Prophase microtubule arrays undergo flux-like behavior in mammalian cells. Ferenz NP, Wadsworth P. Molecular biology of the cell. 2007 18:3993-4002. [PubMed:17671163] [PMC:PMC1995704]

DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement. Jang CY, Wong J, Coppinger JA, Seki A, Yates JR, Fang G. The Journal of cell biology. 2008 181:255-67. [PubMed:18411309] [PMC:PMC2315673]

Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a. Jang CY, Coppinger JA, Seki A, Yates JR, Fang G. Journal of cell science. 2009 122:1334-41. [PubMed:19351716] [PMC:PMC2671931]

Poleward transport of TPX2 in the mammalian mitotic spindle requires dynein, Eg5, and microtubule flux. Ma N, Tulu US, Ferenz NP, Fagerstrom C, Wilde A, Wadsworth P. Molecular biology of the cell. 2010 21:979-88. (ICC; Pig) [PubMed:20110350] [PMC:PMC2836978]

Human KIF2A (Sandwich ELISA) ELISA Kit - LS-F8230

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$834

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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