KIDINS220 / ARMS

kinase D-interacting substrate, 220kDa

Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration By similarity. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

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Proteins (2)

Type

Over-Expression Lysate (2)

Target

KIDINS220 / ARMS (2)

Publications

No (2)

Tag

Myc-DDK (Flag) (2)

Species

Human (1)

Source

293T Cells (1)

HEK 293 Cells (1)

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Human KIDINS220 / ARMS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86498

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

196.4 kDa

Price:

20 µg/$215

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KIDINS220 / ARMS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G111048

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

196.4 kDa

Price:

100 µg/$710

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