KIAA1811 / BRSK1

BR serine/threonine kinase 1

Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

KIAA1811 / BRSK1 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human KIAA1811 / BRSK1 Protein (Recombinant GST, N-terminus) (aa289-380) - LS-G63374

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human KIAA1811 / BRSK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92285

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

84.9 kDa

Price:

20 µg/$215

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KIAA1811 / BRSK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G108819

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

84.9 kDa

Price:

100 µg/$710

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