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KIAA0517 / TRIM2
tripartite motif containing 2
KIAA0517 / TRIM2 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants.
| Gene Name: | tripartite motif containing 2 |
| Family/Subfamily: | Tripartite Motif |
| Synonyms: | TRIM2, KIAA0517, RNF86, RING finger protein 86, Tripartite motif containing 2, Tripartite motif protein 2, Tripartite motif protein TRIM2, Tripartite motif-containing 2 |
| Target Sequences: | NM_015271 NP_056086.2 Q9C040 |
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