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KHDRBS3 / SLM2
KH domain containing, RNA binding, signal transduction associated 3
RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro.
| Gene Name: | KH domain containing, RNA binding, signal transduction associated 3 |
| Synonyms: | KHDRBS3, Etle, Etoile, RNA-binding protein T-Star, T-STAR, SALP, SLM-2, SLM2, TSTAR, Sam68-like mammalian protein 2 |
| Target Sequences: | NM_006558 NP_006549.1 |
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