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KF1 / RNF103
ring finger protein 103
KF1 / RNF103 contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene.
| Gene Name: | ring finger protein 103 |
| Synonyms: | RNF103, HKF-1, ZFP-103, ZFP103, KF-1, KF1, Ring finger protein 103 |
| Target Sequences: | NM_005667 NP_005658.1 O00237 |
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