KDR / VEGFR2 / FLK1

kinase insert domain receptor (a type III receptor tyrosine kinase)

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.

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Products

Proteins (34)

Type

Over-Expression Lysate (2)

Recombinant (32)

Target

KDR / VEGFR2 / FLK1 (34)

Application

Bind (3)

ELISA (1)

Func (1)

SDS-PAGE (9)

Publications

No (34)

Tag

AVI-6His, C-terminus (1)

DDK,C-terminus (2)

Fc (3)

Fc, C-terminus (3)

GST (1)

GST, N-terminus (1)

His (5)

His, N-Terminal (1)

His,C-terminus (5)

His-GST (2)

His-GST, N-terminus (1)

His-S (1)

Human IgG Fc, C-terminus (4)

Myc-DDK (Flag) (2)

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Species

Human (22)

Mouse (7)

Pig (1)

Rat (3)

Source

293F Cells (1)

293T Cells (1)

Baculovirus (2)

CHO Cells (1)

E. coli (5)

HEK 293 Cells (10)

Human (2)

Human Cells (7)

Mammalian Cells (2)

Sf9 Cells (2)

Wheat Germ Extract (1)

more less

Purification

Purified (6)

Low Endotoxin Level

Low endotoxin level (23)

Biologically Active

Biologically active (8)

Select

Human KDR / VEGFR2 / FLK1 Protein (Recombinant Human IgG Fc, C-terminus) (Met1-Glu764) - LS-G47161

Source:

HEK 293 Cells

Tag:

Human IgG Fc, C-terminus

Application:

Bind ELISA Func SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human VEGFR2/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 979 amino acids and predicts a molecular mass of 109 kDa. The apparent molecular mass of rh VEGFR2/Fc monomer is approximatly 150-160 in SDS-PAGE under reducing conditions.

Price:

100 µg/$480; 1 mg/$2,324

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Mouse KDR / VEGFR2 / FLK1 Protein (Recombinant His) (aa46-322) - LS-G13736

Source:

E. coli

Tag:

His

Molecular Weight:

32.7 kDa

Price:

10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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Rat KDR / VEGFR2 / FLK1 Protein (Recombinant His-S) (aa46-320) - LS-G13737

Source:

E. coli

Tag:

His-S

Molecular Weight:

36.8 kDa

Price:

10 µg/$263; 50 µg/$343; 200 µg/$662; 100 µg/$530; 1 mg/$1,657; 500 µg/$1,242; 5 mg/$2,600; 2 mg/$1,832

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Human KDR / VEGFR2 / FLK1 Protein (Recombinant Human IgG Fc, C-terminus) (Met1-Lys327) - LS-G47205

Source:

HEK 293 Cells

Tag:

Human IgG Fc, C-terminus

Application:

SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human KDR consists of 549 amino acids and predicts a molecular mass of 61.5 kDa.

Price:

200 µg/$633

Select

Human KDR / VEGFR2 / FLK1 Protein (Recombinant Human IgG Fc, C-terminus) (Asp120-Lys327) - LS-G47191

Source:

HEK 293 Cells

Tag:

Human IgG Fc, C-terminus

Application:

SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human KDR consists of 449 amino acids and predicts a molecular mass of 50.4 kDa.

Price:

200 µg/$633

Select

Human KDR / VEGFR2 / FLK1 Protein (Recombinant His,C-terminus) (Met1-Lys327) - LS-G47816

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human KDR consists of 319 amino acids and predicts a molecular mass of 35.9 kDa.

Price:

200 µg/$633

Select

Human KDR / VEGFR2 / FLK1 Protein (Recombinant His,C-terminus) (Asp120-Lys327) - LS-G47817

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human KDR consists of 219 amino acids and predicts a molecular mass of 24.8 kDa.

Price:

200 µg/$633

Select

Human KDR / VEGFR2 / FLK1 Protein (Recombinant His,C-terminus) (Met1-Glu764) - LS-G47818

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

Bind SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The secreted recombinant human VEGFR2 consists of 756 amino acids and predicts a molecular mass of 84.6 kDa. The apparent molecular mass of rhVEGFR2 is approximatly 120-130 in SDS-PAGE under reducing conditions.

Price:

100 µg/$480; 1 mg/$2,324

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Human KDR / VEGFR2 / FLK1 Protein (Recombinant His-GST, N-terminus) (Asp807-Val1356) - LS-G47832

Source:

Baculovirus

Tag:

His-GST, N-terminus

Application:

SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human KDR /GST chimera consists of 787 amino acids and has a calculated molecular mass of 89.3 kDa. The recombinant protein migrates as an approximately 110 kDa band in SDS-PAGE under reducing conditions.

Price:

50 µg/$410; 500 µg/$1,735

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Mouse KDR / VEGFR2 / FLK1 Protein (Recombinant Fc, C-terminus) - LS-G146250

Source:

Human

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

110 kDa

Price:

10 µg/$273; 50 µg/$398

Select

Human KDR / VEGFR2 / FLK1 Protein (Recombinant DDK,C-terminus) - LS-G142445

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

83.3 kDa

Price:

20 µg/$677

Select

Human KDR / VEGFR2 / FLK1 Protein (Recombinant DDK,C-terminus) - LS-G142446

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

37.2 kDa

Price:

20 µg/$677

Select

Human KDR / VEGFR2 / FLK1 Protein (Recombinant AVI-6His, C-terminus) - LS-G146108

Source:

Human

Tag:

AVI-6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

86.1 kDa

Price:

20 µg/$416; 100 µg/$910

Select

Human KDR / VEGFR2 / FLK1 Protein (Recombinant GST) (aa20-764) - LS-G20892

Source:

E. coli

Tag:

GST

Molecular Weight:

110.6 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Pig KDR / VEGFR2 / FLK1 Protein (Recombinant His-GST) (aa8-290) - LS-G24298

Source:

E. coli

Tag:

His-GST

Molecular Weight:

61.1 kDa

Price:

10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334

Select

Mouse KDR / VEGFR2 / FLK1 Protein (Recombinant His,C-terminus) (Met1-Glu762) - LS-G48932

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant mouse KDR consists of 754 amino acids and predicts a molecular mass of 84.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmKDR is approximately 100-110 kDa as a result of glycosylation.

Price:

100 µg/$441; 1 mg/$2,003

Select

Mouse KDR / VEGFR2 / FLK1 Protein (Recombinant Human IgG Fc, C-terminus) (Met1-Glu762) - LS-G49025

Source:

HEK 293 Cells

Tag:

Human IgG Fc, C-terminus

Application:

Bind SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant mouse KDR /Fc comprises 984 amino acids and has a predicted molecular mass of 110 kDa. The apparent molecular mass of the protein is approximately 120 kDa in SDS-PAGE under reducing conditions due to glycosylation.

Price:

100 µg/$441; 1 mg/$2,003

Select

Human KDR / VEGFR2 / FLK1 Protein (Recombinant Fc) (Met1-Glu764) - LS-G98014

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

109 kDa

Price:

100 µg/$926; 1 mg/$4,701

Select

Mouse KDR / VEGFR2 / FLK1 Protein (Recombinant Fc) (Met1-Glu762) - LS-G98200

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

110 kDa

Price:

100 µg/$721

Select

Mouse KDR / VEGFR2 / FLK1 Protein (Recombinant His) (Met1-Glu762) - LS-G98201

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

84.5 kDa

Price:

100 µg/$721

Select

Human KDR / VEGFR2 / FLK1 Protein (Recombinant GST, N-terminus) (aa31-130) - LS-G59064

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human KDR / VEGFR2 / FLK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79537

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

152 kDa

Price:

20 µg/$215

Select

Human KDR / VEGFR2 / FLK1 Protein (Recombinant His) (Met1-Glu764) - LS-G98686

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

84.6 kDa

Price:

100 µg/$926; 1 mg/$4,701

Select

KDR / VEGFR2 / FLK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99710

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

152 kDa

Price:

100 µg/$710

Select

Rat KDR / VEGFR2 / FLK1 Protein (Recombinant His) (Met1-Glu760) - LS-G98430

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

84.3 kDa

Price:

50 µg/$721

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