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Unfortunately, the antibody (ID:156226) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



KDR / VEGFR2 / FLK1

kinase insert domain receptor (a type III receptor tyrosine kinase)

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.

Gene Name: kinase insert domain receptor (a type III receptor tyrosine kinase)
Family/Subfamily: Protein Kinase , VEGF Receptor
Synonyms: KDR, CD309, Fetal liver kinase 1, Fetal liver kinase-1, FLK-1, FLK1, Kinase insert domain receptor, Quek1, VEGFR, VEGFR2, Soluble VEGFR2, VEGF receptor 2, VEGFR-2, CD309 antigen, VEGF-R2
Target Sequences: NM_002253 NP_002244.1 P35968

Publications (10)

1
Receptor chimeras indicate that the vascular endothelial growth factor receptor-1 (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cells. Rahimi N, Dayanir V, Lashkari K. The Journal of biological chemistry. 2000 275:16986-92. (WB, IP) [PubMed:10747927]
2
Vascular endothelial growth factor and hepatocyte growth factor levels are differentially elevated in patients with advanced retinopathy of prematurity. Lashkari K, Hirose T, Yazdany J, McMeel JW, Kazlauskas A, Rahimi N. The American journal of pathology. 2000 156:1337-44. (IHC-P; Human) [PubMed:10751359] [PMC:PMC1876877]
3
The carboxyl terminus controls ligand-dependent activation of VEGFR-2 and its signaling. Meyer RD, Singh AJ, Rahimi N. The Journal of biological chemistry. 2004 279:735-42. (WB, IP) [PubMed:14573614] [PMC:PMC1464116]
4
The carboxyl terminus of VEGFR-2 is required for PKC-mediated down-regulation. Singh AJ, Meyer RD, Band H, Rahimi N. Molecular biology of the cell. 2005 16:2106-18. (WB, IP) [PubMed:15673613] [PMC:PMC1073687]
5
Expression of periostin in human breast cancer. Puglisi F, Puppin C, Pegolo E, Andreetta C, Pascoletti G, D'Aurizio F, Pandolfi M, Fasola G, Piga A, Damante G, Di Loreto C. Journal of clinical pathology. 2008 61:494-8. [PubMed:17938160]
6
Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Hu-Lowe DD, Zou HY, Grazzini ML, Hallin ME, Wickman GR, Amundson K, Chen JH, Rewolinski DA, Yamazaki S, Wu EY, McTigue MA, Murray BW, Kania RS, O'Connor P, Shalinsky DR, Bender SL. Clinical cancer research : an official journal of the American Association for Cancer Research. 2008 14:7272-83. [PubMed:19010843]
7
Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue. Rey S, Luo W, Shimoda LA, Semenza GL. Blood. 2011 117:4988-98. [PubMed:21389314] [PMC:PMC3100705]
8
Rosuvastatin improves vascular function of arteriovenous fistula in a diabetic rat model. Roan JN, Fang SY, Chang SW, Hsu CH, Huang CC, Chiou MH, Tsai YC, Lam CF. Journal of vascular surgery. 2012 56:1381-9.e1. (Flo; Rat) [PubMed:22727844]
9
Molecular MRI differentiation of VEGF receptor-2 levels in C6 and RG2 glioma models. He T, Smith N, Saunders D, Pittman BP, Lerner M, Lightfoot S, Silasi-Mansat R, Lupu F, Towner RA. American journal of nuclear medicine and molecular imaging. 2013 3:300-11. (WB; Human) [PubMed:23901356] [PMC:PMC3715774] Related Antibodies: LS-C117508.
10
The gene expression of human endothelial cells is modulated by subendothelial extracellular matrix proteins: short-term response to laminar shear stress. Chlupac J, Filova E, Havlikova J, Matejka R, Riedel T, Houska M, Brynda E, Pamula E, R[Character e9]my M, Bareille R, Fernandez P, Daculsi R, Bourget C, Bacakova L, Bordenave L. Tissue engineering. Part A. 2014 Aug;20:2253-64. [Full Text Article] [PubMed:24606163] [PMC:PMC4137337] Related Antibodies: LS-C109100.
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Filtered By: None
Target
kdr-vegfr2-flk1 (271)
Reactivity
Human (208)
Mouse (143)
Rat (81)
Bovine (4)
Chimpanzee (3)
Dog (5)
Drosophila melanogaster (1)
Gibbon (3)
Hamster (1)
Horse (4)
Monkey (5)
Pig (15)
Sheep (1)
Zebrafish (1)
Application
IHC (125)
IHC-Fr (5)
IHC-P (38)
WB (220)
Flo (35)
DB (8)
ELISA (101)
Func (1)
ICC (23)
IF (34)
IP (9)
Neut (1)
Peptide-ELISA (10)
Host
rabbit (219)
mouse (45)
e. coli (1)
rat (6)
Isotype
IgG (140)
IgG1 (21)
IgG1,k (4)
IgG2a (4)
IgG2a,k (14)
IgG2b,k (8)
Clonality
monoclonal mc (53)
polyclonal pc (218)
Clone
12C1 (1)
23B31 (1)
2A1 (1)
2A2 (1)
2D7 (1)
4B4 (1)
89B3A5 (1)
Avas12a1 (4)
EIC (1)
EWC (1)
FLK-6 (3)
KDR657 (2)
KDR721 (2)
Format
AP Conjugated (10)
APC (6)
APC Conjugated (17)
Azide-free (3)
Biotin Conjugated (24)
Cy3 Conjugated (6)
Cy7 Conjugated (6)
DY488 Conjugated (3)
DY550 Conjugated (3)
DY650 Conjugated (3)
FITC Conjugated (21)
HRP Conjugated (18)
Magnetic beads Conjugated (1)
PE Conjugated (20)
scFv (1)
Sepharose Conjugated (1)
Unconjugated (138)
Epitope
C-Terminus (17)
aa46-320 (17)
pTyr1175 (15)
pTyr951 (15)
aa8-290 (10)
pTyr996 (10)
Tyr1175 (9)
aa46-322 (9)
pTyr1214 (9)
Internal (8)
aa1326-1356 (8)
aa920-949 (8)
Extracellular Domain (5)
pTyr1059 (5)
aa252-301 (4)
aa786-1356 (3)
aa1158-1345 (2)
aa1300-1367 (2)
pTyr1054 (2)
Asp1209 (1)
Gln1169 (1)
Ile1053 (1)
N-Terminus (1)
aa 20-764 (1)
aa1020-1069 (1)
aa1025-1074 (1)
aa1057-1061 (1)
aa1110-1190 (1)
aa1141-1190 (1)
aa1150-1230 (1)
aa1158-1365 (1)
aa1180-1229 (1)
aa1200-1300 (1)
aa20-762 (1)
aa29-60 (1)
aa454-469 (1)
aa890-970 (1)
aa917-966 (1)
aa990-1070 (1)
pTyr1054/Tyr1059 (1)
Publications
No (269)
Yes (2)
Showing 1-25 out of 271 results
Anti-KDR / VEGFR2 / FLK1 Antibody (Internal) IHC-plus™ LS-A9456
Anti-KDR / VEGFR2 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Rabbit Polyclonal to Human KDR / VEGFR2 / FLK1
Dog, Human, Monkey
IHC IHC-P
Unconjugated
Anti-KDR / VEGFR2 / FLK1 Antibody (aa1300-1367) IHC-plus™ LS-B669
Anti-VEGFR2 antibody IHC of human placenta, endothelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B669 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rabbit Polyclonal to Mouse KDR / VEGFR2 / FLK1
Mouse, Human
ICC IF IHC IHC-P WB
Unconjugated
Anti-KDR / VEGFR2 / FLK1 Antibody (Internal) IHC-plus™ LS-A9457
Anti-KDR / VEGFR2 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Rabbit Polyclonal to Human KDR / VEGFR2 / FLK1
Human
IHC IHC-P
Unconjugated
Anti-KDR / VEGFR2 / FLK1 Antibody (clone 4B4) LS-C109100
Confocal immunofluorescence of HeLa (left) and HepG2 (right) cells using KDR mouse monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye.
Western blot using KDR mouse monoclonal antibody against extracellular domain of human KDR (aa20-764).

Mouse Monoclonal [clone 4B4] (IgG1) to Human KDR / VEGFR2 / FLK1
Human
ELISA Flo
Unconjugated
Anti-KDR / VEGFR2 / FLK1 Antibody (Extracellular Domain) LS-C122532

Mouse Monoclonal (IgG1) to Human KDR / VEGFR2 / FLK1
Human
IHC IHC-Fr IHC-P WB
Unconjugated
Anti-KDR / VEGFR2 / FLK1 Antibody LS-C88674
Formalin-fixed, paraffin-embedded human angiosarcoma stained with peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of tumor cells.  This image was taken for the unmodified form of this product. Other forms have not been tested.

Rabbit Polyclonal (IgG) to Mouse KDR / VEGFR2 / FLK1
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
Anti-KDR / VEGFR2 / FLK1 Antibody (Azide-free) LS-C88675
Formalin-fixed, paraffin-embedded human angiosarcoma stained with peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of tumor cells.  This image was taken for the unmodified form of this product. Other forms have not been tested.

Rabbit Polyclonal (IgG) to Mouse KDR / VEGFR2 / FLK1
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated, Azide-free
Anti-KDR / VEGFR2 / FLK1 Antibody (clone Avas12a1, PE) LS-C105970
Surface staining of bEnd.3 cells with anti-mouse Flk-1 (Avas12a1) PE. Appropriate isotype controls were used (open histogram). Total viable cells were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rat Monoclonal [clone Avas12a1] (IgG2a,k) to Mouse KDR / VEGFR2 / FLK1
Mouse
Flo
PE Conjugated
Anti-KDR / VEGFR2 / FLK1 Antibody (aa20-762, Biotin) LS-C36367

Mouse Monoclonal (IgG) to Human KDR / VEGFR2 / FLK1
Human
ELISA
Biotin Conjugated
Anti-KDR / VEGFR2 / FLK1 Antibody (aa1158-1345) LS-C45503

Mouse Monoclonal (IgG1) to Mouse KDR / VEGFR2 / FLK1
Mouse, Human
ELISA IHC IHC-P WB
Unconjugated
Anti-KDR / VEGFR2 / FLK1 Antibody (aa1020-1069) LS-C117937
Immunofluorescence of HeLa cells, using VEGFR2 (Ab-1054) Antibody. The picture on the right is treated with the synthesized peptide.

Rabbit Polyclonal (IgG) to Human KDR / VEGFR2 / FLK1
Mouse, Rat, Human
IF IHC Peptide-ELISA
Unconjugated
Anti-KDR / VEGFR2 / FLK1 Antibody (clone Avas12a1) LS-C106629

Rat Monoclonal [clone Avas12a1] (IgG2a,k) to Mouse KDR / VEGFR2 / FLK1
Mouse
Flo WB
Unconjugated
Anti-KDR / VEGFR2 / FLK1 Antibody (phospho-Tyr1214) LS-C117508
IHC of paraffin-embedded human breast carcinoma, using VEGFR2 (Phospho-Tyr1214) Antibody. The picture on the right is treated with the synthesized peptide.
Western blot of extracts from HepG2 cells treated with Na3VO4 0.3 nM 40', using VEGFR2 (Phospho-Tyr1214) Antibody. The lane on the right is treated with the synthesized peptide.

Rabbit Polyclonal (IgG) to Human KDR / VEGFR2 / FLK1
Mouse, Rat, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
Anti-KDR / VEGFR2 / FLK1 Antibody (aa1150-1230) LS-C383547
Western blot of Flk-1 antibody

Rabbit Polyclonal (IgG) to Human KDR / VEGFR2 / FLK1
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
Anti-KDR / VEGFR2 / FLK1 Antibody LS-C92366

Mouse Monoclonal (IgG1) to Human KDR / VEGFR2 / FLK1
Rat, Human
ELISA Flo IHC IHC-Fr
Unconjugated
Anti-KDR / VEGFR2 / FLK1 Antibody (phospho-Tyr1175) LS-C40131

Rabbit Monoclonal (IgG) to Human KDR / VEGFR2 / FLK1
Drosophila melanogaster, Mouse, Human
ELISA ICC IF WB
Unconjugated
Anti-KDR / VEGFR2 / FLK1 Antibody LS-C194996
IHC of VEGFR2 antibody. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using VEGFR2 antibody (left) or the same antibody preincubated with with blocking peptide (right)
Immunofluorescent staining using VEGFR2 antibody. Immunofluorescence staining of methanol-fixed MCF cells using VEGFR2 antibody

Rabbit Polyclonal to Human KDR / VEGFR2 / FLK1
Mouse, Rat, Human
ICC IHC IHC-P WB
Unconjugated
Anti-KDR / VEGFR2 / FLK1 Antibody (aa1326-1356) LS-C97533
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Confocal immunofluorescence of VEGFR2 (FLK1/KDR) Antibody with HeLa cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

Rabbit Polyclonal to Human KDR / VEGFR2 / FLK1
Human
Flo IF IHC IHC-P WB
Unconjugated
Anti-KDR / VEGFR2 / FLK1 Antibody (C-Terminus) LS-C368408
Immunohistochemical analysis of VEGFR2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of VEGFR2 staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

Rabbit Polyclonal to Human KDR / VEGFR2 / FLK1
Human
ICC IF IHC IHC-P WB
Unconjugated
Anti-KDR / VEGFR2 / FLK1 Antibody LS-C194812

Mouse Monoclonal (IgG1) to Human KDR / VEGFR2 / FLK1
Human
ELISA ICC IHC WB
Unconjugated
Anti-KDR / VEGFR2 / FLK1 Antibody (Extracellular Domain, clone FLK-6, Magnetic beads) LS-C171148

Mouse Monoclonal [clone FLK-6] (IgG1) to Human KDR / VEGFR2 / FLK1
Human
IP
Magnetic beads Conjugated
Anti-KDR / VEGFR2 / FLK1 Antibody (C-Terminus) LS-C76789

Rabbit Polyclonal (IgG) to Mouse KDR / VEGFR2 / FLK1
Mouse, Rat, Human
IF IHC WB
Unconjugated
Anti-KDR / VEGFR2 / FLK1 Antibody (Extracellular Domain, clone 23B31) LS-C193580

Mouse Monoclonal [clone 23B31] (IgG1) to Human KDR / VEGFR2 / FLK1
Human
Flo IP Neut WB
Unconjugated
Anti-KDR / VEGFR2 / FLK1 Antibody (phospho-Tyr951) LS-C40132

Rabbit Monoclonal (IgG) to Human KDR / VEGFR2 / FLK1
Mouse, Human
ELISA IHC IHC-P WB
Unconjugated
Anti-KDR / VEGFR2 / FLK1 Antibody (clone 89B3A5) LS-C85124

Rat Monoclonal [clone 89B3A5] (IgG2a) to Mouse KDR / VEGFR2 / FLK1
Mouse, Human
Flo IP WB
Unconjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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