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KDM6B / JMJD3

lysine (K)-specific demethylase 6B

Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.

Gene Name:	lysine (K)-specific demethylase 6B
Synonyms:	KDM6B, JMJD3, Jumonji domain containing 3, Lysine-specific demethylase 6B, KIAA0346, Lysine demethylase 6B
Target Sequences:	AB002344 BAA21572.2 O15054

Publications (3)

Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes. Shaw T, Martin P. EMBO reports. 2009 10:881-6. [PubMed:19575012] [PMC:PMC2726669]

Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells. Lu TY, Lu RM, Liao MY, Yu J, Chung CH, Kao CF, Wu HC. The Journal of biological chemistry. 2010 285:8719-32. [PubMed:20064925] [PMC:PMC2838295] Related Antibodies: LS-C96527.

Evidence for alteration of EZH2, BMI1, and KDM6A and epigenetic reprogramming in human papillomavirus type 16 E6/E7-expressing keratinocytes. Hyland PL, McDade SS, McCloskey R, Dickson GJ, Arthur K, McCance DJ, Patel D. Journal of virology. 2011 85:10999-1006. [PubMed:21865393] [PMC:PMC3194988] Related Antibodies: LS-C96527.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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