KDM5A / JARID1A

lysine (K)-specific demethylase 5A

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1.

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Proteins (4)

Type

Recombinant (4)

Target

KDM5A / JARID1A (4)

Publications

No (4)

Tag

DDK,C-terminus (1)

GST (1)

His (1)

His-SUMO (1)

Species

Human (4)

Source

E. coli (1)

Sf9 Cells (1)

Yeast (1)

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Human KDM5A / JARID1A Protein (Recombinant GST) - LS-G132116

Tag:

GST

Molecular Weight:

36.74kDa

Price:

10 µg/$479; 25 µg/$670

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Human KDM5A / JARID1A Protein (Recombinant DDK,C-terminus) - LS-G142439

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

192 kDa

Price:

20 µg/$677

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Human KDM5A / JARID1A Protein (Recombinant His-SUMO) (aa437-603) - LS-G20891

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

35.3 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human KDM5A / JARID1A Protein (Recombinant His) (aa437-603) - LS-G22993

Source:

Yeast

Tag:

His

Molecular Weight:

21.3 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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