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KDM4C / JMJD2C

lysine (K)-specific demethylase 4C

Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.

Gene Name: lysine (K)-specific demethylase 4C
Synonyms: KDM4C, BA146B14.1, GASC-1 protein, GASC1, Jumonji domain containing 2C, JMJD2C, JHDM3C, KIAA0780, Lysine-specific demethylase 4C
Target Sequences: AB037901 BAB16102.1 Q9H3R0

Publications (2)

1
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. Luo W, Chang R, Zhong J, Pandey A, Semenza GL. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:E3367-76. (ChrIP; Human) [PubMed:23129632] [PMC:PMC3523832]
2
iPSC-Derived Embryoid Bodies as Models of c-Met-Mutated Hereditary Papillary Renal Cell Carcinoma. Jin Wook Hwang, Christophe Desterke, Olivier Féraud, Stephane Richard, Sophie Ferlicot, Virginie Verkarre, Jean Jacques Patard, Julien Loisel-Duwattez, Adlen Foudi, Frank Griscelli, Annelise Bennaceur-Griscelli, Ali G Turhan. International journal of molecular sciences. 2019 September;20: [Full Text Article] [PubMed:31575031] [PMC:PMC6801716] Related Antibodies: LS-C114684.

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
KDM4C / JMJD2C (4)
No (4)
His (1)
Myc-DDK (Flag) (3)
Human (3)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
KDM4C / JMJD2C Protein - Purified recombinant protein KDM4C was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
119.8 kDa
20 µg/$1,107
KDM4C / JMJD2C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
119.8 kDa
20 µg/$150
KDM4C / JMJD2C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
119.8 kDa
100 µg/$494
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E. coli
His
22.6 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).