Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
|Gene Name:||lysine (K)-specific demethylase 4C|
|Synonyms:||KDM4C, BA146B14.1, GASC-1 protein, GASC1, Jumonji domain containing 2C, JMJD2C, JHDM3C, KIAA0780, Lysine-specific demethylase 4C|
|Target Sequences:||AB037901 BAB16102.1 Q9H3R0|
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