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KDM4B / JMJD2B
lysine (K)-specific demethylase 4B
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
| Gene Name: | lysine (K)-specific demethylase 4B |
| Synonyms: | KDM4B, JHDM3B, Lysine-specific demethylase 4B, KIAA0876, JMJD2B, Jumonji domain containing 2B |
| Target Sequences: | AB020683 BAA74899.2 O94953 |
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