KDM4A / JHDM3A / JMJD2A

lysine (K)-specific demethylase 4A

Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.

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Products

Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

KDM4A / JHDM3A / JMJD2A (4)

Publications

No (4)

Tag

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

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Human KDM4A / JHDM3A / JMJD2A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90023

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

120.5 kDa

Price:

20 µg/$150

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Human KDM4A / JHDM3A / JMJD2A Protein (Recombinant His-T7) (aa141-310) - LS-G25794

Source:

E. coli

Tag:

His-T7

Molecular Weight:

23.5 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human KDM4A / JHDM3A / JMJD2A Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71541

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

120.5 kDa

Price:

20 µg/$1,107

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KDM4A / JHDM3A / JMJD2A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101255

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

120.5 kDa

Price:

100 µg/$494

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