KDM4A / JHDM3A / JMJD2A

lysine (K)-specific demethylase 4A

Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.

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Products

ELISA Kits (1)

Type

Sandwich (1)

Target

KDM4A / JHDM3A / JMJD2A (1)

Reactivity

Human (1)

Format

96-Well Strip Plate (1)

Publications

No (1)

Sample Type

Cell Lysates (1)

Tissue Homogenates (1)

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Human KDM4A / JHDM3A / JMJD2A (Sandwich ELISA) ELISA Kit - LS-F8937

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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