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KDM2B / FBXL10
lysine (K)-specific demethylase 2B
Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
| Gene Name: | lysine (K)-specific demethylase 2B |
| Family/Subfamily: | F-Box |
| Synonyms: | KDM2B, CXXC2, Fbl10, F-box/LRR-repeat protein 10, JHDM1B, F-box protein FBL10, FBXL10, Lysine-specific demethylase 2B, PCCX2, Protein JEMMA |
| Target Sequences: | AL133572 CAB63721.2 Q8NHM5 |
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