KDELR3

KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 3

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified, and it encodes a protein highly homologous to KDELR1 and KDELR2 proteins. Two transcript variants of KDELR3 that arise by alternative splicing, and encode different isoforms of KDELR3 receptor, have been described.

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Proteins (5)

Type

Over-Expression Lysate (4)

Recombinant (1)

Target

KDELR3 (5)

Publications

No (5)

Tag

GST (1)

Myc-DDK (Flag) (4)

Species

Human (3)

Source

293T Cells (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Purified (1)

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KDELR3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115012

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.8 kDa

Price:

100 µg/$494

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KDELR3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112529

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25.5 kDa

Price:

100 µg/$494

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Human KDELR3 Protein (Recombinant GST) (Full Length) - LS-G32455

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

49.28 kDa

Price:

10 µg/$479; 25 µg/$670

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Human KDELR3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85320

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.8 kDa

Price:

20 µg/$150

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Human KDELR3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85321

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25.5 kDa

Price:

20 µg/$150

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