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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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KDELR3

KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 3

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified, and it encodes a protein highly homologous to KDELR1 and KDELR2 proteins. Two transcript variants of KDELR3 that arise by alternative splicing, and encode different isoforms of KDELR3 receptor, have been described.

Gene Name: KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 3
Synonyms: KDELR3
Target Sequences: NM_016657 NP_057839.1 O43731

Filtered By: None
Target
KDELR3 (8)
Reactivity
Human (8)
Mouse (4)
Bat (4)
Bovine (4)
Chimpanzee (3)
Dog (4)
Horse (4)
Monkey (4)
Pig (4)
Rabbit (4)
Application
IHC (2)
IHC-P (1)
WB (8)
ELISA (1)
Peptide-ELISA (1)
Host
rabbit (8)
Isotype
IgG (2)
Clonality
polyclonal pc (8)
Format
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (5)
Epitope
aa71-120 (4)
30-110 aa, Internal (1)
Leu95 (1)
aa61-110 (1)
Publications
No (8)
Showing 1-8 of 8 results

KDELR3 Antibody (30-110 aa, Internal) LS-C384247
Rabbit Polyclonal (IgG) to Human KDELR3
Mouse, Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of KDEL Receptor 3 antibody
Western blot of KDEL Receptor 3 antibody

KDELR3 Antibody (Leu95) LS-C177373
Rabbit Polyclonal to Human KDELR3
Mouse, Human
IHC IHC-P WB
Unconjugated
100µl  $345.00
IHC of KDEL Receptor 3 (L95) pAb in paraffin-embedded human brain tissue.
Western blot of KDEL Receptor 3 (L95) pAb in extracts from 3T3 cells.
IHC of KDEL Receptor 3 (L95) pAb in paraffin-embedded human brain tissue.
Western blot of KDEL Receptor 3 (L95) pAb in extracts from 3T3 cells.

KDELR3 Antibody (aa61-110) LS-C119963
Rabbit Polyclonal (IgG) to Human KDELR3
Mouse, Human
Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Western blot analysis of lysates from NIH/3T3 cells, using ERD23 Antibody. The lane on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from NIH/3T3 cells, using ERD23 Antibody. The lane on the right is blocked with the synthesized peptide.

KDELR3 Antibody (aa71-120) LS-C111120
Rabbit Polyclonal to Human KDELR3
Rabbit, Dog, Bovine, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
50µg  $365.00
KDELR3 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
KDELR3 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

KDELR3 Antibody (aa71-120, HRP) LS-C449235
Rabbit Polyclonal to Human KDELR3
Rabbit, Dog, Bovine, Pig, Horse, Bat, Human, Monkey, Chimpanzee
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
KDELR3 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
KDELR3 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

KDELR3 Antibody (aa71-120, Biotin) LS-C449233
Rabbit Polyclonal to Human KDELR3
Rabbit, Dog, Bovine, Pig, Horse, Bat, Human, Monkey, Chimpanzee
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
KDELR3 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
KDELR3 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

KDELR3 Antibody (aa71-120, FITC) LS-C449234
Rabbit Polyclonal to Human KDELR3
Rabbit, Dog, Bovine, Pig, Horse, Bat, Human, Monkey, Chimpanzee
WB
FITC Conjugated
100µl 1mg/ml  $385.00
KDELR3 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
KDELR3 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

KDELR3 Antibody LS-C416307
Rabbit Polyclonal to Human KDELR3
Mouse, Human
WB
Unconjugated
100µg 1mg/ml  $305.00
Western blot of NIH-3T3 cell lysate using ERD23 Antibody
Western blot of NIH-3T3 cell lysate using ERD23 Antibody
Showing 1-8 of 8 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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