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KCNQ2
potassium voltage-gated channel, KQT-like subfamily, member 2
Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors.
| Gene Name: | potassium voltage-gated channel, KQT-like subfamily, member 2 |
| Family/Subfamily: | Ion Channel , Potassium channel - KCNQ |
| Synonyms: | KCNQ2, BFNS1, BFNC, EBN, EBN1, EIEE7, HNSPC, KQT2, KV7.2, KCNA11, KQT-like 2, ENB1, KVEBN1 |
| Target Sequences: | NM_004518 NP_004509.2 O43526 |
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