KCNK18 / TRESK

potassium channel, subfamily K, member 18

Outward rectifying potassium channel. Produces rapidly activating outward rectifier K+ currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

KCNK18 / TRESK (3)

Publications

No (3)

Tag

GST (1)

Myc-DDK (Flag) (2)

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Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Purified (1)

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Human KCNK18 / TRESK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G93542

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.5 kDa

Price:

20 µg/$150

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Human KCNK18 / TRESK Protein (Recombinant GST) (Full Length) - LS-G37278

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

69.19 kDa

Price:

10 µg/$479; 25 µg/$670

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KCNK18 / TRESK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102517

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.5 kDa

Price:

100 µg/$494

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