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KCNH2 / HERG

potassium voltage-gated channel, subfamily H (eag-related), member 2

Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.

Gene Name:	potassium voltage-gated channel, subfamily H (eag-related), member 2
Family/Subfamily:	Ion Channel , Potassium channel - Eag-related
Synonyms:	KCNH2, Eag homolog, HERG-1, ERG1, HERG, KV11.1, M-erg1, H-ERG, HERG1, SQT1, LQT2, Merg1, Eag-related protein 1, ERG-1
Target Sequences:	NM_000238 NP_000229.1 Q12809

Publications (2)

Interaction with GM130 during HERG ion channel trafficking. Disruption by type 2 congenital long QT syndrome mutations. Human Ether--go-go-Related Gene. Roti EC, Myers CD, Ayers RA, Boatman DE, Delfosse SA, Chan EK, Ackerman MJ, January CT, Robertson GA. The Journal of biological chemistry. 2002 277:47779-85. [PubMed:12270925]

Cardiac IKr channels minimally comprise hERG 1a and 1b subunits. Jones EM, Roti Roti EC, Wang J, Delfosse SA, Robertson GA. The Journal of biological chemistry. 2004 279:44690-4. [PubMed:15304481]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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